Evidence map›Paper›PMID 41809239›Full record

Trial reportOpen forum infectious diseases2026

Effectiveness of Doxycycline in Combination With Other Antibiotics for Gram-Positive Periprosthetic Joint Infections: A Causal Inference Study.

Jeanne Godon, Amadou-Khalilou Sow, Sylvia Das Neves, Coralie Humann, Alice Bordet, Ludovic Labattut, Thibault Sixt, Lucie Amoureux, Valentin Pineau, Christine Binquet and 3 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jeanne GodonCentre de Référence Interrégional Pour la Prise en Charge des Infections Ostéo-Articulaires Complexes (CRIOAc Dijon), Dijon, France.
Amadou-Khalilou SowCHU Dijon Bourgogne, Centre d'Investigation Clinique, Module Épidémiologie Clinique, INSERM, CIC1432, Université Bourgogne Europe, Dijon, France.ORCID https://orcid.org/0000-0001-8073-9128
Sylvia Das NevesCentre de Référence Interrégional Pour la Prise en Charge des Infections Ostéo-Articulaires Complexes (CRIOAc Dijon), Dijon, France.
Coralie HumannDépartement de Rhumatologie, Hôpital Universitaire Dijon-Bourgogne, Dijon, France.
Alice BordetCentre de Référence Interrégional Pour la Prise en Charge des Infections Ostéo-Articulaires Complexes (CRIOAc Dijon), Dijon, France.
Ludovic LabattutCentre de Référence Interrégional Pour la Prise en Charge des Infections Ostéo-Articulaires Complexes (CRIOAc Dijon), Dijon, France.ORCID https://orcid.org/0000-0003-1643-8974
Thibault SixtCentre de Référence Interrégional Pour la Prise en Charge des Infections Ostéo-Articulaires Complexes (CRIOAc Dijon), Dijon, France.ORCID https://orcid.org/0000-0002-2966-6346
Lucie AmoureuxCentre de Référence Interrégional Pour la Prise en Charge des Infections Ostéo-Articulaires Complexes (CRIOAc Dijon), Dijon, France.ORCID https://orcid.org/0000-0003-0763-0921
Valentin PineauService des Maladies Infectieuses et Tropicales, Hôpital Universitaire de Nantes, Nantes, France.
Christine BinquetCHU Dijon Bourgogne, Centre d'Investigation Clinique, Module Épidémiologie Clinique, INSERM, CIC1432, Université Bourgogne Europe, Dijon, France.ORCID https://orcid.org/0000-0002-9417-5754
Sophie MahyCentre de Référence Interrégional Pour la Prise en Charge des Infections Ostéo-Articulaires Complexes (CRIOAc Dijon), Dijon, France.
Lionel PirothCentre de Référence Interrégional Pour la Prise en Charge des Infections Ostéo-Articulaires Complexes (CRIOAc Dijon), Dijon, France.ORCID https://orcid.org/0000-0003-4478-1032
Mathieu BlotCentre de Référence Interrégional Pour la Prise en Charge des Infections Ostéo-Articulaires Complexes (CRIOAc Dijon), Dijon, France.ORCID https://orcid.org/0000-0001-6541-2434

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Doxycycline is occasionally used as step-down therapy in periprosthetic joint infections (PJI), but evidence supporting its efficacy is limited. This study aimed to estimate the effect of doxycycline on 12-month treatment failure in patients with gram-positive PJI. Methods: Adult patients with hip, knee, or shoulder PJI caused by Results: Three hundred and eighty-six patients with PJI (median age 72 years, interquartile range [IQR] = 65-80) were analyzed. Most infections involved the hip (62%) were caused by Conclusions: Doxycycline in combination with other antibiotics was not associated with 12-month treatment failure in PJI caused by

Indexed as

causal inference studydoxycyclinegram-positive bacteriaIPTWperiprosthetic joint infectionSBWStaphylococcus aureusTMLEtreatment failure

Identifiers

PMID41809239
PMCPMC12968137

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.