ArticleWorld journal of gastrointestinal pharmacology and therapeutics2026
Impact of sedation on adenoma and polyp detection rates and cecal intubation in elderly patients undergoing screening colonoscopy.
Article in World journal of gastrointestinal pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIncreasing age is a major risk factor for colorectal neoplasia, with older adults showing a higher incidence of adenomas compared to individuals under 60 years. Early detection of colonic adenomas and polyps significantly reduces the risk of colorectal cancer. Key quality indicators for colonoscopy include the adenoma detection rate (ADR), polyp detection rate (PDR), and cecal intubation rate (CIR). However, studies comparing these metrics in elderly patients deeply sedated with propofol
aimTo evaluate deep propofol sedation
methodsThis retrospective cohort study included adults over 60 years who underwent their first screening colonoscopy between January 2017 and September 2023. Exclusion criteria were emergency procedures, inflammatory bowel disease, procedures performed for therapeutic intent, and inadequate bowel preparation [Boston Bowel Preparation Scale (BBPS) score below 6]. Normality was tested by the Kolmogorov-Smirnov test; continuous variables were compared by the Mann-Whitney
resultsA total of 2034 patients (46.4% female; mean age: 70 years) were included, of whom 622 (30.6%) underwent colonoscopy under deep sedation. The overall PDR was 51.65%, ADR was 33.3%, and CIR was 94.25%. After adjusting for confounders [age, sex, body mass index (BMI), BBPS, operation, and diverticulosis], no significant differences were observed in PDR (51.8%
conclusionIn this elderly cohort, propofol-induced deep sedation did not significantly improve ADR, PDR, or CIR. Further research is warranted to clarify its effect on colonoscopy quality metrics in older populations.
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