ArticleWorld journal of gastrointestinal pharmacology and therapeutics2026
Fully covered metal biliary stents confer a higher risk of post-endoscopic retrograde cholangiopancreatography pancreatitis.
Article in World journal of gastrointestinal pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBiliary fully-covered self-expanding metal stents (FCSEMS) are increasingly used over plastic or uncovered SEMS due to their long-term patency and removability. However, there is concern that transpapillary placement may lead to post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).
aimTo assess the rates of PEP with and without the use of FCSEMS for both benign and malignant indications.
methodsWe performed a multicenter retrospective cohort study involving three Australian tertiary referral centers. Consecutive adults who underwent ERCP for biliary indications between October 2016 and October 2019 were included. The primary endpoint was the rate of PEP. Secondary endpoints included severity of pancreatitis, other procedure- and stent-related adverse events occurring within 90 days.
resultsA total of 3401 ERCPs were performed (54.2% female, mean age 62.9±18.6 years) with an overall PEP rate of 3.15%. On propensity-score matched analysis, FCSEMS was an independent predictor of PEP (odds ratio = 5.49, 95% confidence interval: 2.10-6.99;
conclusionBiliary FCSEMS are associated with a higher risk of PEP compared to no stents or plastic stents, particularly for benign indications.
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