ReviewCurrent therapeutic research, clinical and experimental2026
Conduction of Pragmatic Clinical Trials in Routine Clinical Settings: Guidelines for Development of Protocol.
Review in Current therapeutic research, clinical and experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The relationships between treatments and real-world healthcare outcomes can be effectively evaluated through the implementation of a pragmatic clinical trial or practical clinical trial (PCT). Objective: This trial helps to bridge the gap between clinical research and real-world practice by providing valuable insights into treatment effectiveness in routine health care settings. This article aims to present a systematic approach for developing study protocols by combining the author's real-world experience from study center and knowledge derived from existing literature. Methods: This brief review article is based on a focused literature review and the author's academic experience in developing study protocol for academic research using PCT design. The core methodology components, such as research question formation, site selection, feasibility testing, and sample size calculation, are presented in a stepwise manner to guide protocol development. Results: The study outlines a structured approach that can be applied in routine health care practice. The stepwise approach aids in the systematic planning and execution of PCT, ensuring their feasibility and relevance in real-world clinical settings. Conclusions: This article serves as a practical guide for future trialists and researchers interested in adopting the PCT design. It also aims to raise awareness among those unfamiliar with this approach, offering an alternative perspective beyond traditional randomized controlled trials. clinical trial registry of India: CTRI/2025/03/081559.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.