Evidence map›Paper›PMID 41809158›Full record

ArticleWorld journal of methodology2026

Are iris masses in lung carcinoma always a metastasis: Two case reports.

Bhagabat Nayak, Prasanta Raghab Mohapatra, Koyel Chakraborty, Jayadev Nanda, Shri Haripriya, Satya Padmaja Mantha, Madhusmita Sethy, Bijnya Birajita Panda

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of methodology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Bhagabat NayakDepartment of Ophthalmology, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India.
Prasanta Raghab MohapatraDepartment of Pulmonary Medicine, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India.
Koyel ChakrabortyDepartment of Ophthalmology, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India.
Jayadev NandaDepartment of Ophthalmology, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India.
Shri HaripriyaDepartment of Ophthalmology, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India.
Satya Padmaja ManthaDepartment of Pulmonary Medicine and Critical Care, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India.
Madhusmita SethyDepartment of Pathology, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India.
Bijnya Birajita PandaDepartment of Ophthalmology, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India. bigyan_panda@yahoo.co.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmall cell lung cancer (SCLC) constitutes about 15% of lung cancers and is an aggressive disease with uveal metastasis. An isolated iris lesion in such patients may or may not be a manifestation of disseminated disease. We report two cases - one patient with SCLC and another with non-small cell lung cancer, each with varied presentation. CASE SUMMARY: The first case was a 49-year-old female who presented with redness in the left eye. She was a known case of SCLC with multi-organ involvement. The best corrected visual acuity (BCVA) was 20/100. Slit-lamp bio-microscopy showed an iris mass with neovascularization. Cytology from anterior chamber paracentesis was suggestive of malignancy. Subsequently she received whole-brain radiotherapy followed by six cycles of platinum doublet chemotherapy. On follow-up, the iris lesion subsided with BCVA of 20/50. The second case was a 54-year-old female with lung adenocarcinoma and brain metastasis. She presented with pain and redness in the right eye (BCVA 20/200). Slit lamp bio-microscopy showed multiple iris nodules in the affected eye. Trabeculectomy was done due to raised intraocular pressure (IOP). Aqueous tap and tissue biopsy for cytology and histopathology respectively, were negative for secondaries. Postoperatively, BCVA improved to 20/70, with an IOP of 12 mmHg and resolution of the nodules.

conclusionIris lesions in lung carcinoma patients may not necessarily be metastases. Sometimes they can be reactive nodules mimicking secondaries.

Indexed as

Case reportIris metastasisIris nodulesLung adenocarcinomaOsimertinibSmall cell lung cancer

Identifiers

PMID41809158
PMCPMC12968780

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