ArticleThe journal of allergy and clinical immunology. Global2026
Correlation between IL-17 levels and chronic urticaria: Systematic review and meta-analysis.
Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Recent advances have elucidated the pivotal role of IL-17 in the pathogenesis of psoriasis, with breakthroughs in biologics modulating IL-17 signaling pathways. However, emerging evidence suggests a potential association between IL-17 and chronic urticaria (CU). Some studies have quantified IL-17 and related cytokines in CU cohorts to unravel their pathophysiologic contributions and therapeutic implications. Objective: This study conducted an evidence-based systematic review to evaluate the pathologic role of IL-17 in CU. Methods: Comprehensive searches were performed across Chinese and English biomedical databases, including CNKI, Wanfang, Sinomed, PubMed, and Web of Science, to collect clinical studies investigating the association between IL-17 and CU from database inception to December 31, 2024. Meta-analysis was performed by RevMan 5.4, with effect sizes calculated by a random-effects model. Results: A total of 37 eligible clinical studies were included, comprising 2,630 CU patients and 1,731 healthy controls. Meta-analysis revealed that serum IL-17 levels in CU patients were significantly higher than in controls, with a standardized mean difference of 2.71 (95% confidence interval, 2.28-3.15; Conclusion: As a key effector cytokine of the T
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