ArticleFrontiers in nutrition2026
Epicardial adipose tissue volume is associated with impaired left atrial mechanics in hypertensive overweight/obese patients: the potential mediating role of insulin resistance.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Epicardial adipose tissue (EAT) is implicated in cardiovascular disease, but its specific impact on left atrial (LA) mechanics in hypertensive overweight/obese patients remains unclear. We investigated the association between EAT volume (EATV) and LA dysfunction in this high-risk population. Methods: In this cross-sectional study, 264 hypertensive overweight/obese patients (body mass index ≥24 kg/m Results: The high-EATV group had significantly higher TyG-BMI and longer hypertension duration. Despite comparable conventional echocardiographic parameters, this group demonstrated impaired LA mechanics, evidenced by reduced LAs-s, LAs-e, and LAs-a, alongside elevated LASI. EATV was inversely correlated with LA strains (LAs-s, LAs-e, LAs-a) but positively correlated with both TyG-BMI and LASI. After multivariable adjustment, EATV remained independently associated with LAs-s, LAs-a, and LASI. Mediation analysis indicated that TyG-BMI explained 12.87% of the association between EATV and LAs-s, and 10.00% of the association between EATV and LASI. Conclusion: Increased EATV is independently associated with impaired LA mechanics in hypertensive overweight/obese patients. Insulin resistance, assessed by TyG-BMI, may partly explain these associations, linking epicardial adiposity to early atrial dysfunction.
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