Evidence map›Paper›PMID 41809095›Full record

ArticleBioactive materials2026

Dual-function thermoresponsive antibiotic-loaded hydrogel with antimicrobial and osteogenic properties for implant-related infection control.

Caroline Dini, Stéfany Barbosa Alves da Cruz, Rodolfo D Piazza, Bruna E Nagay, Rodrigo F C Marques, Renato C V Casarin, Fang Yang, Magda Feres, Jet Liu, Batbileg Bor and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Caroline DiniDepartment of Prosthodontics and Periodontology, Universidade Estadual de Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, São Paulo, 13414-903, Brazil.
Stéfany Barbosa Alves da CruzDepartment of Diagnosis and Surgery, Sao Paulo State University (UNESP), School of Dentistry at Aracatuba, Araçatuba, São Paulo, 16015-050, Brazil.
Rodolfo D PiazzaLaboratory of Magnetic Materials and Colloids (LaMMC), Physical Chemistry Department, Sao Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo, 14800-900, Brazil.
Bruna E NagayDepartment of Prosthodontics and Periodontology, Universidade Estadual de Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, São Paulo, 13414-903, Brazil.
Rodrigo F C MarquesLaboratory of Magnetic Materials and Colloids (LaMMC), Physical Chemistry Department, Sao Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo, 14800-900, Brazil.
Renato C V CasarinDepartment of Prosthodontics and Periodontology, Universidade Estadual de Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, São Paulo, 13414-903, Brazil.
Fang YangRegenerative Biomaterials, Dentistry, Radboudumc, 6500, HB Nijmegen, the Netherlands.
Magda FeresDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Massachusetts, 02115, USA.
Jet LiuInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA.
Batbileg BorDepartment of Microbiology, ADA Forsyth Institute, Somerville, MA, 02143, USA.
Edilson ErvolinoDepartment of Basic Science, Sao Paulo State University (UNESP), School of Dentistry at Aracatuba, Araçatuba, São Paulo, 16015-050, Brazil.
Liqun XuBRICS Joint Laboratory on Biomedical Materials, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China.
Erica D de AvilaDepartment of Diagnosis and Surgery, Sao Paulo State University (UNESP), School of Dentistry at Aracatuba, Araçatuba, São Paulo, 16015-050, Brazil.
Leonardo P FaveraniDepartment of Oral Diagnosis, Division of Oral and Maxillofacial Surgery, Universidade Estadual de Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, São Paulo, 13414-903, Brazil.
João Gabriel S SouzaDental Research Division, Guarulhos University (UNG), Guarulhos, São Paulo, 07011-010, Brazil.
Jeroen Jjp van den BeuckenRegenerative Biomaterials, Dentistry, Radboudumc, 6500, HB Nijmegen, the Netherlands.
Valentim A R BarãoDepartment of Prosthodontics and Periodontology, Universidade Estadual de Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, São Paulo, 13414-903, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implant-related infections demand advanced biomaterials capable of delivering localized, sustained antimicrobial activity while supporting tissue repair. Here, we present an engineered thermoresponsive hydrogel based on poly(N-vinylcaprolactam) (PNVCL), designed as a dual-function platform that enables temperature-triggered gelation, controlled tetracycline release, and osteogenic support. The PNVCL network was tailored to provide rapid sol-gel transition at physiological temperature, strong adhesion to moist surfaces, injectability into narrow implant geometries, high swelling capacity, slow degradation, and a stable drug-release profile-properties rarely combined within a single hydrogel system. To evaluate material performance, we employed a tiered biological framework comprising cytocompatibility assays, controlled physicochemical analyses, and antimicrobial testing against complex, polymicrobial biofilms, complemented by human

Indexed as

Antibacterial agentsDental implantsHydrogelPeri-implant infectionsTetracyclineTitanium

Identifiers

PMID41809095
PMCPMC12969315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.