ReviewRSC advances2026
Kabbe condensation: a comprehensive review of spirochromanone synthesis and medicinal applications.
Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
The Kabbe reaction is an organic condensation reaction that specifically involves an enamine and 2-hydroxy acetophenone reacting to form a spirochromanone skeleton. This review covers various methods and advancements, highlighting a range of Kabbe products, particularly spirochromanones, which are heterocycles exhibiting significant biological activities. The Kabbe method incorporates ring-closing metathesis (RCM), the synthesis of annulated chalcone conjugates, natural product synthesis, base-catalyzed reactions, organo-catalysis, Mukaiyama-Kabbe adaptations, organocatalytic variants, redox-mediated processes, and dual or sequential condensations. Consequently, researchers in this domain will find this overview valuable and beneficial towards the synthesis of various Kabbe products in the synthesis of spirochromanones, spirochromanone-chalcone hybrids, carbamide molecular hybrids, and spirochromanone-flavanone hybrids. This review provides a comprehensive overview of spirochromanones and their derivatives, covering literature from their inception up to 2025.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.