Evidence map›Paper›PMID 41809039›Full record

ArticleiScience2026

Cerebral organoid exosomes reversed behavioral deficits by repressing NLRP3-mediated neuroinflammation in stress models.

Yuhan Duan, Shaocong Zhou, Dongao Zeng, Shuaiguang Shi, Aoying Chen, Fangzhou Du, Yue Wu, Jingwen Wang, Shuang Yu, Jingzhong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuhan DuanSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei Baohe District, Hefei 230026, China.
Shaocong ZhouSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei Baohe District, Hefei 230026, China.
Dongao ZengSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei Baohe District, Hefei 230026, China.
Shuaiguang ShiSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei Baohe District, Hefei 230026, China.
Aoying ChenSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei Baohe District, Hefei 230026, China.
Fangzhou DuSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
Yue WuSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
Jingwen WangSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
Shuang YuSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei Baohe District, Hefei 230026, China.
Jingzhong ZhangSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei Baohe District, Hefei 230026, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression, a highly prevalent neuropsychiatric disorder, involves neuroinflammation in its pathophysiology. Exosomes have emerged as a promising strategy for modulating neuroinflammation, however, the potential of cerebral organoid (CO)-derived exosomes (OExos) in regulating neuroinflammation and their efficacy in treating depression remain unexplored. Using induced pluripotent stem cell-derived cerebral organoids containing neural progenitors, neurons, and glia, we demonstrated through proteomics that OExo modulate depression-associated inflammatory pathways by coordinately regulating NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome cascade.

Indexed as

biological sciencesneurosciencestem cells research

Identifiers

PMID41809039
PMCPMC12969089

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.