Evidence map›Paper›PMID 41808921›Full record

ArticleJournal of the Royal Statistical Society. Series B, Statistical methodology2026

Inference on function-valued parameters using a restricted score test.

Aaron Hudson, Marco Carone, Ali Shojaie

Abstract read
In one paragraph

Article in Journal of the Royal Statistical Society. Series B, Statistical methodology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aaron HudsonVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Marco CaroneDepartment of Biostatistics, University of Washington, Seattle, USA.
Ali ShojaieDepartment of Biostatistics, University of Washington, Seattle, USA.

Funding

Statistical Methods for Incorporating Machine Learning Tools in Inference and Large-Scale Surveillance using Electronic Medical Records DataR01HL137808 · NHLBI · UNIVERSITY OF WASHINGTON · PI CARONE, MARCO · 2019 to 2023
$2.4M
Machine Learning Tools for Discovery and Analysis of Active Metabolic PathwaysR01GM114029 · NIGMS · UNIVERSITY OF WASHINGTON · PI SHOJAIE, ALI · 2016 to 2020
$1.7M
Novel Statistical Inference for Biomedical Big DataR01GM133848 · NIGMS · UNIVERSITY OF WASHINGTON · PI SHOJAIE, ALI · 2020 to 2023
$1.7M
NHLBI NIH HHS R01 HL137808NIGMS NIH HHS R01 GM114029NIGMS NIH HHS R01 GM133848
6 · The paper itself

Abstract

It is often of interest to make inference on an unknown function that is a local parameter of the data-generating mechanism, such as a density or regression function. Such estimands can typically only be estimated at a slower-than-parametric rate in nonparametric and semiparametric models, and performing calibrated inference can be challenging. In many cases, these estimands can be expressed as the minimizer of a population risk functional. Here, we propose a general framework that leverages such representation and provides a nonparametric extension of the score test for inference on an infinite-dimensional risk minimizer. We demonstrate that our framework is applicable in a wide variety of problems. As both analytic and computational examples, we describe how to use our general approach for inference on a mean regression function under (i) nonparametric and (ii) partially additive models, and evaluate the operating characteristics of the resulting procedures via simulations. Assessment of effect heterogeneity, inference on density functions, and conditional independence testing are discussed as additional examples.

Indexed as

Nonparametric testingNon-pathwise differentiabilityScore testSimultaneous confidence bands

Identifiers

PMID41808921
PMCPMC12971076

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.