Evidence map›Paper›PMID 41808901›Full record

ArticleBMJ public health2026

Cost-effectiveness of cancer interventions in Rwanda: literature review and expert elicitation for health benefits package design.

Cassandra Nemzoff, Andres Madriz-Montero, Inga Mumukunde, Jean Marie Vianney Sindambiwe, Isabelle de Valois Ndishimye, Valentine Uyisabye, James Humuza, Rob Baltussen, Regis Hitimana, Sedona Sweeney and 2 more

Abstract read
In one paragraph

Article in BMJ public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cassandra NemzoffLondon School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0003-2735-0644
Andres Madriz-MonteroLondon School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0001-8114-8039
Inga MumukundeClinton Health Access Initiative, Kigali, Rwanda.
Jean Marie Vianney SindambiweUniversity of Rwanda, School of Public Health, Kigali, Rwanda.
Isabelle de Valois NdishimyeUniversity of Rwanda, School of Public Health, Kigali, Rwanda.ORCID https://orcid.org/0009-0008-5003-6155
Valentine UyisabyeUniversity of Rwanda, School of Public Health, Kigali, Rwanda.
James HumuzaUniversity of Rwanda, School of Public Health, Kigali, Rwanda.
Rob BaltussenRadboud University Medical Center, Nijmegen, Netherlands.ORCID https://orcid.org/0000-0002-8364-2847
Regis HitimanaRwanda Social Security Board, Kigali, Rwanda.
Sedona SweeneyLondon School of Hygiene and Tropical Medicine, London, UK.
Stella Matutina UmuhozaUniversity of Rwanda, School of Public Health, Kigali, Rwanda.
Anna VassallLondon School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0002-2911-1375

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Prioritising health benefits packages (HBPs) that specify which health services are covered under insurance is sometimes done in disease-specific clusters. Cancer is a good candidate for this, given its high cost and rising disease burden, particularly in low- and middle-income countries.The Government of Rwanda assessed 49 cancers against nine criteria to inform the design of its HBP. Each cancer had a basic, core and enhanced package of services, and one preventive intervention was assessed, totalling 148 interventions. This paper focuses on the results of one criterion: cost-effectiveness. The objectives were to specify which cost-effectiveness methods were selected and why; to assess the cost-effectiveness of 148 cancer interventions; and to recommend how to strengthen the global cost-effectiveness evidence base. Methods: Methods were selected using an adaptive health technology assessment approach, by considering the trade-offs between available time, data and capacity. The assessment undertook a review of the Tufts cost-effectiveness assessment (CEA) registry and filled evidence gaps with structured expert elicitation. Analysts summarised lessons learnt to recommend improvements to the global cost-effectiveness evidence base. Results: Of the 148 cost-effectiveness ratios (CERs) sought, 39 were from the Tufts registry and 83 were expert elicited. Limited availability of CERs from the literature resulted in a disproportionate number of CERs being elicited from experts. Analysts recommend better reporting and improved consistency in the extraction of CEAs to support HBP design. Conclusion: This is the first study to assess the cost-effectiveness of many cancers simultaneously for HBP design. It highlights the strengths and limitations of existing evidence and demonstrates the feasibility of combining rapid review with expert elicitation to obtain replicable CER estimates. These cost-effectiveness findings were used to prioritise a package of cancer services for Rwanda alongside several other criteria (reported separately).

Indexed as

economicsmethodsPublic Health

Identifiers

PMID41808901
PMCPMC12970044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.