Evidence map›Paper›PMID 41808887›Full record

ReviewWorld journal of stem cells2026

Therapeutic applications of mesenchymal stem cell-derived extracellular vesicles in pain management: A narrative review of emerging evidence and future directions.

Sara Akhtar Khan, Prakash Gangadaran, Prachi Tiwari, Ramya Lakshmi Rajendran, Azfar Jamal, Shaheenkousar H Hattiwale, Kushi Anand, Saurabh Kumar Jha, Chae Moon Hong, Byeong-Cheol Ahn and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of stem cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sara Akhtar KhanDepartment of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, Delhi, India.
Prakash GangadaranDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, South Korea.
Prachi TiwariDepartment of Physiotherapy, School of Nursing Sciences and Allied Health, Jamia Hamdard, New Delhi 110062, Delhi, India.
Ramya Lakshmi RajendranDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, South Korea.
Azfar JamalDepartment of Biology, College of Science Al-Zulfi, Majmaah University, Al-Majmaah 11952, Saudi Arabia.
Shaheenkousar H HattiwaleDepartment of Basic Medical Sciences, College of Medicine, Majmaah University, Al-Majmaah 11952, Saudi Arabia.
Kushi AnandDepartment of Life Sciences, School of Biological and Forensic Science, Kristu Jayanti (Deemed to be University), Bangalore 560077, Karnātaka, India.
Saurabh Kumar JhaDepartment of Zoology, Kalindi College, University of Delhi, Delhi 110008, India.
Chae Moon HongDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, South Korea.
Byeong-Cheol AhnDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, South Korea.
Suhel ParvezDepartment of Medical Elementology and Toxicology, Jamia Hamdard, New Delhi 110062, Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pain remains a major clinical challenge because current therapies often have limited efficacy and substantial adverse effects. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are emerging as promising candidates with anti-inflammatory, immunomodulatory, and neuroprotective actions. Preclinical studies show that MSC-EVs alleviate inflammatory, neuropathic, and cancer-related pain by modulating immune responses and promoting neural repair, thereby reducing nociceptor sensitization. MSC-EVs also hold potential as drug-delivery vehicles and as biomarkers for pain diagnosis due to their stability and bioactive cargo (

Indexed as

BiomarkersDrug deliveryImmunomodulationMesenchymal stem cell-derived extracellular vesiclesNociceptor sensitizationPain management

Identifiers

PMID41808887
PMCPMC12968799

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.