Evidence map›Paper›PMID 41808882›Full record

ArticleCase reports in cardiology2026

Culture-Negative Infective Endocarditis Presenting With Cardio-Hepatorenal Syndrome in a 21-Year-Old Patient: A Case Report of Diagnostic Workup and Management.

Jana Kotaich, Safaa Ghanem, Nour Mina, Rayyan El Saleh, Rim Awada, Said Chaaban, Karim Jammal

Abstract read
In one paragraph

Article in Case reports in cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jana KotaichDepartment of Internal Medicine, MEDICA Research Investigation, Hadath, Lebanon.ORCID https://orcid.org/0000-0002-7740-392X
Safaa GhanemDepartment of Internal Medicine, MEDICA Research Investigation, Hadath, Lebanon.ORCID https://orcid.org/0009-0000-0702-1144
Nour MinaDepartment of Internal Medicine, MEDICA Research Investigation, Hadath, Lebanon.ORCID https://orcid.org/0000-0002-2477-4583
Rayyan El SalehDepartment of Internal Medicine, MEDICA Research Investigation, Hadath, Lebanon.ORCID https://orcid.org/0000-0001-6446-3192
Rim AwadaDepartment of Internal Medicine, MEDICA Research Investigation, Hadath, Lebanon.ORCID https://orcid.org/0000-0001-6133-597X
Said ChaabanDepartment of Cardiology, Hammoud Hospital University Medical Center, Saida, Lebanon, hammoudhospital.com.
Karim JammalDepartment of Cardiology, Hammoud Hospital University Medical Center, Saida, Lebanon, hammoudhospital.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infective endocarditis (IE) imposes a challenge in clinical practice, often demanding rapid and precise identification of the causative agent to guide tailored therapeutic interventions. However, a subset of cases presents an elusive diagnostic dilemma with culture-negative results, thereby complicating the management strategy. This case report sheds light on a particularly rare instance of culture-negative IE in a 21-year-old previously healthy male who presented with dyspnea and jaundice, emphasizing the scarcity of such cases in the existing medical literature. Through a detailed examination of clinical manifestations, diagnostic modalities, and treatment outcomes, we aim to contribute valuable insights into the nuanced aspects of culture-negative IE. Furthermore, this report underscores the imperative need for clinicians to maintain a high index of suspicion for IE, even in the absence of positive cultures, to ensure timely and appropriate management for improved patient prognosis.

Indexed as

cardio-hepatorenal syndromechallengeechocardiograminfective endocarditisviral infection

Identifiers

PMID41808882
PMCPMC12968723

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.