ArticleFrontiers in immunology2026
Generation and characterization of human induced pluripotent stem cells from neuropathologically confirmed multiple system atrophy patient-derived fibroblasts.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Multiple system atrophy (MSA) is an adult-onset, fatal neurodegenerative disease, classified as a synucleinopathy along with Parkinson's disease and dementia with Lewy bodies. The etiology of MSA is unknown and the treatment remains symptomatic with limited efficacy. To date most studies have been conducted on genetic mice models, engineered to overexpress α-synuclein (aSyn); and transmission mice models, treated with intracerebral injections of MSA brain extracts or fibrillar aSyn which can be assembled Method: For this purpose, we report the generation of six fully characterized induced pluripotent stem cells (iPSCs) lines, which were reprogrammed from disease-derived skin fibroblasts and represent the two major clinical MSA variants with either predominant parkinsonism (MSA-P) or cerebellar dysfunction (MSA-C). Five of these cases received postmortem neuropathological confirmation of definite MSA diagnosis. Results: The generated iPSC clones meet the International Society for Stem Cell Research (ISSCR) quality standards for genomic stability and functional pluripotency to ensure experimental reproducibility. None of the clones acquired genetic abnormalities after the reprogramming and the extended culture passage, as evaluated by G-banded karyotyping and digital PCR targeting recurrent iPSC copy number variant hotspots. All the clones expressed pluripotent markers as NANOG, LIN28A and SSEA4 and differentiated efficiently into each of the three embryonic germ layers. Furthermore, we assessed their potential for disease modeling by generating oligodendrocytes (OLs), since the pathologic hallmark of MSA is the aberrant accumulation of aSyn within OLs cytoplasm. We obtained both O4+ oligodendrocyte progenitor cells and MBP+ mature oligodendrocyte cells. Conclusion: We have created a robust and valuable iPSC collection aimed at correlating the
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