ArticleFrontiers in immunology2026
Glycine receptors in circulating white blood cells regulated by neuroinflammation.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Closed-Loop Neuromodulation for Brain Fatigue: From Real-Time Biomarkers to Adaptive Intervention.International journal of molecular sciences · 2026Review
- Synaptic vs. Non-Synaptic Glycine Receptors: Physiological Role and Implications in Alzheimer's Disease Pathology.International journal of molecular sciences · 2026Review
- Glycine as a Metabolic Regulator of Reproductive Function in Livestock: From Gametes to Early Embryos.Animals : an open access journal from MDPI · 2026Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Neuroinflammation is involved in a wide range of neurological disorders, yet the lack of minimally invasive biomarkers hampers early diagnosis and therapeutic monitoring. Glycine receptors (GlyRs), classically known as inhibitory neurotransmitter receptors in the central nervous system, are increasingly recognized as regulators of immune signaling. Here, we identify GlyRs as novel peripheral indicators of neuroinflammation. Methods and results: We demonstrate that GlyRα1, α2, and α3 subunits are constitutively expressed in human and murine immune cells, with GlyRα2 predominating across peripheral tissues and the brain. Using ex vivo and Conclusion: Together, these findings define a brain-glycinergic signaling-blood axis that maintains homeostatic protectivity. GlyR subunits, particularly GlyRα1 and α3, represent a neuropathology-induced modulation of GlyR signaling in peripheral immune cells.
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