ArticleFrontiers in immunology2026
An update on the characterization of immunoglobulin loci in
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: We previously reported the genomic characterization of immunoglobulin loci in Methods: Using our previously annotated AmbMex60DD sequences, we performed an alignment-based annotation followed by manual curation on the UKY_AmexF1_1 assembly. Gene models were further refined using RNA-Seq datasets from axolotl spleen, liver, lung, heart, and gill tissues. Results: The IGH locus was mapped at 350-364 Mbp on chromosome 13q. Synteny is preserved between both genome versions, but in UKY_AmexF1_1, all IGH genes share the same transcriptional orientation. A major difference was observed in the lambda locus, which in the UKY_Amex_F1_1 genome contains 13 IGLC-IGLJ clusters comprising 60 IGLJ genes, compared with only three clusters in the AmbMex60DD genome. No kappa locus was detected in either assembly. Conclusion: This study confirms our previous findings and provides an example of intraspecies structural variation in adaptive immune receptor loci. It underscores the importance of well-assembled genomes and establishes the current
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