Evidence map›Paper›PMID 41808689›Full record

ArticleThe Lancet regional health. Southeast Asia2026

Invasive mould infections of the central nervous system in the Indian population: a cohort study (2004-2025).

Harsimran Kaur, Shivaprakash M Rudramurthy, Rimjhim Kanaujia, Haseen Ahmad, Pravin Salunke, Deepak Bansal, Kirti Gupta, Debajyoti Chatterjee, Chirag Kamal Ahuja, Aastha Takkar Kapila and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet regional health. Southeast Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Harsimran KaurDepartment of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Shivaprakash M RudramurthyDepartment of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Rimjhim KanaujiaDepartment of Medical Microbiology, Dr. Ram Manohar Lohia Institute of Medical Sciences (RMLIMS), Lucknow, 226021, India.
Haseen AhmadDepartment of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Pravin SalunkeDepartment of Neurosurgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Deepak BansalDepartment of Paediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Kirti GuptaDepartment of Histopathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Debajyoti ChatterjeeDepartment of Histopathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Chirag Kamal AhujaDepartment of Radiodiagnosis, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Aastha Takkar KapilaDepartment of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Manish ModiDepartment of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Sandeep MohindraDepartment of Neurosurgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Rajesh ChhabraDepartment of Neurosurgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Madhivanan KarthigeyanDepartment of Neurosurgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Harpreet SinghDepartment of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Apinderpreet SinghDepartment of Neurosurgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Ashish AgarwalDepartment of Neurosurgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Sanjay VermaDepartment of Paediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Sunil Kumar GuptaDepartment of Neurosurgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Sanjay JainDepartment of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Amita TrehanDepartment of Paediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Sameer VyasDepartment of Radiodiagnosis, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Vignesh PandiarajanDepartment of Paediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Anup GhoshDepartment of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Arunaloke ChakrabartiDoodhadhari Burfani Hospital and Research Institute, Haridwar, Uttarakhand, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Central nervous system (CNS) invasive mould infection (IMI) is a rare but life-threatening condition. Limited large-scale studies hinder the understanding of its clinical characteristics and optimal management strategies. Methods: This was a cohort study. We reviewed confirmed patients of CNS IMI (January 2004-March 2025) by microbiological (direct microscopy and/or culture) and/or histopathological evidence at our tertiary care hospital. Clinical, demographic and mycological characteristics were analysed and compared. Findings: Among 1321 brain abscess/biopsy samples, 127 patients (9.6%) were of fungal origin (adults, 100; paediatrics, 27). The median age was 30 (IQR: 27) years, with male predominance (71.7%). Adults were significantly infected by melanized fungi (p = 0.003). Seventy-four percent of patients had no identifiable underlying immunocompromising condition. The median duration of symptoms was 15 days (IQR: 23 days), including headache (61.4%) and seizures (50.4%). Frequency of fever was significantly higher in infection by melanized fungi (p = 0.02). Frontal lobe involvement was common in paediatric age (OR 0.379, 95% CI 0.141-1.019; p = 0.05). Interpretation: We describe a compendium of CNS IMI in patients from India, highlighting distinct clinical patterns and treatment outcomes across age groups and fungal types. This warrants investigation of host and pathogen-related factors in the country. Funding: Funding included Department of Science and Technology-Science and Engineering Research Board (DST-SERB), New Delhi, India and Indian Council of Medical Research (ICMR), New Delhi, India.

Indexed as

Aspergillus spp.Brain abscessCentral nervous systemCerebral phaeohyphomycosisCladophialophora bantianaIndiaInvasive mould infections

Identifiers

PMID41808689
PMCPMC12969336

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.