ArticleOpen access rheumatology : research and reviews2026
A Cross-Sectional Study of the Relationship Between Disease Activity and Fatigue in Rheumatoid Arthritis Patients at King Abdulaziz University Hospital, Saudi Arabia.
Article in Open access rheumatology : research and reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Fatigue beyond inflammation in inflammatory rheumatic diseases: a narrative review and treatable-traits framework.Rheumatology international · 2026Review
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2 authors.
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Abstract
Background: Fatigue is one of the most prevalent and disabling symptoms in patients with rheumatoid arthritis (RA), yet its relationship with disease activity remains complex and underexplored in many populations. Objective: To evaluate the association between disease activity and fatigue in RA patients at King Abdulaziz University Hospital using validated clinical measures. Methods: A cross-sectional study was conducted among 253 RA patients fulfilling the ACR/EULAR 2010 classification criteria. Disease activity was assessed using the Clinical Disease Activity Index (CDAI), and fatigue was measured with the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale. Relationships between fatigue (FACIT-F scores) and CDAI were examined using Pearson correlation with continuous CDAI scores. Descriptive statistics (mean ± SD) of FACIT-F scores across CDAI categories were provided for illustration. Multivariate linear regression adjusted for age, sex, disease duration, body mass index, employment status, serological markers, and treatment type. ANOVA was applied to assess differences in mean FACIT-F scores across disease activity categories. Statistical significance was set at p < 0.05. Results: Fatigue was reported by 80% of patients, with 10% experiencing severe fatigue (FACIT-F ≤13). Mean FACIT-F scores decreased as disease activity increased: remission 40.1 ± 8.2, low disease activity 35.7 ± 10.4, moderate disease activity 25.6 ± 9.8, and high disease activity 15.4 ± 7.3 ( Conclusion: Fatigue in RA is strongly associated with disease activity but persists in patients with well-controlled inflammation, reflecting multifactorial origins. Routine fatigue assessment and holistic management strategies addressing both inflammatory and non-inflammatory contributors are essential to improve patient quality of life and treatment outcomes.
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