ArticleCirculation research2026
Short SCN5A Transcript Yields a NaV1.5 Fragment Influencing Cardiac Metabolism.
Abstract read
In one paragraph
Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- RNA-Binding Proteins Regulate Cardiovascular Disease Progression Through Alternative Splicing and Alternative Polyadenylation.Journal of cardiovascular translational research · 2026Review
- Cardiac Sodium Channel Regulation: A Potential New Therapeutic Target in Cardiomyopathy.Circulation research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Nathan H WitmerDepartment of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center, Carver College of Medicine (N.H.W., J.M.H., J.M.M., C.S.S., J.-Y.Y., B.L., R.L.B.), University of Iowa.ORCID 0000-0002-0369-0305
Jasmyn M HoegerDepartment of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center, Carver College of Medicine (N.H.W., J.M.H., J.M.M., C.S.S., J.-Y.Y., B.L., R.L.B.), University of Iowa.ORCID 0000-0003-2673-059X
Jared M McLendonDepartment of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center, Carver College of Medicine (N.H.W., J.M.H., J.M.M., C.S.S., J.-Y.Y., B.L., R.L.B.), University of Iowa.ORCID 0000-0002-1002-5872
Colleen S SteinDepartment of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center, Carver College of Medicine (N.H.W., J.M.H., J.M.M., C.S.S., J.-Y.Y., B.L., R.L.B.), University of Iowa.ORCID 0000-0002-7676-6278
Jin-Young YoonDepartment of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center, Carver College of Medicine (N.H.W., J.M.H., J.M.M., C.S.S., J.-Y.Y., B.L., R.L.B.), University of Iowa.ORCID 0000-0002-5707-3636
Lili WangDivision of Genetic Medicine and Clinical Pharmacology, Vanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical Center, Nashville, TN (L.W., B.C.K.).ORCID 0000-0002-2746-4521
Elena BerezhnayaDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (E.B., J.W.E.).ORCID 0000-0002-4733-5348
John W ElrodDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (E.B., J.W.E.).ORCID 0000-0003-3925-2224
Björn C KnollmannDivision of Genetic Medicine and Clinical Pharmacology, Vanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical Center, Nashville, TN (L.W., B.C.K.).ORCID 0000-0003-4956-9735
Barry LondonDepartment of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center, Carver College of Medicine (N.H.W., J.M.H., J.M.M., C.S.S., J.-Y.Y., B.L., R.L.B.), University of Iowa.ORCID 0000-0003-1506-3947
Ryan L BoudreauDepartment of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center, Carver College of Medicine (N.H.W., J.M.H., J.M.M., C.S.S., J.-Y.Y., B.L., R.L.B.), University of Iowa.ORCID 0000-0002-9800-5349
Funding
Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Walter J. Koch · 2017 to 2026
$21.0MToward a Mechanism-Based Approach to Treating Cardiac ArrhythmiaR35HL144980 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2019 to 2025
$7.1MSUMOylation of Voltage-Gated Sodium Channels In Neuronal Hyperexcitability of Alzheimer’s DementiaR01HL115955 · NHLBI · UNIVERSITY OF IOWA · PI IRANI, KAIKOBAD J., LONDON, BARRY · 2013 to 2023
$5.4MPredoctoral Training in the Pharmacological SciencesT32GM067795 · NIGMS · UNIVERSITY OF IOWA · PI STRACK, STEFAN · 2004 to 2021
$3.4MA Versatile Chemical-Genetic Approach to Determine Bases for Arrhythmogenesis and Sodium ChannelopathiesR01HL163979 · NHLBI · UNIVERSITY OF IOWA · PI Christopher A Ahern, Barry London · 2023 to 2026
$2.6MGenetic and Molecular Mechanisms of Heart DiseaseR35HL177241 · NHLBI · UNIVERSITY OF IOWA · PI RYAN L BOUDREAU · 2025 to 2026
$2.1MRegulation and role of the cardiac sodium channel Nav1.5 in heart failureR01HL144717 · NHLBI · UNIVERSITY OF IOWA · PI BOUDREAU, RYAN L · 2019 to 2023
$1.9MThe physiologic and genomic relevance of mitoregulin in ischemic heart failureR01HL150557 · NHLBI · UNIVERSITY OF IOWA · PI BOUDREAU, RYAN L · 2020 to 2023
$1.5MMARC at University of IowaT34GM141143 · NIGMS · UNIVERSITY OF IOWA · PI ADAMS-PHILLIPS, LORI C, FORBES, TORI · 2021 to 2024
$1.5MMetabolic pathways in cardiac physiology and heart failureR01HL172926 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI John William Elrod · 2025 to 2026
$1.5MMitochondria and metabolism in neurodegenerationR01NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2024 to 2025
$1.5MHigh Resolution Research UltrasoundS10OD038119 · OD · UNIVERSITY OF IOWA · PI WEISS, ROBERT M · 2025 to 2025
$419kNHLBI NIH HHS P01 HL134608NHLBI NIH HHS R01 HL115955NHLBI NIH HHS R01 HL144717NHLBI NIH HHS R01 HL150557NHLBI NIH HHS R01 HL163979NHLBI NIH HHS R01 HL172926NHLBI NIH HHS R35 HL144980NHLBI NIH HHS R35 HL177241NIGMS NIH HHS T32 GM067795NIGMS NIH HHS T34 GM141143NIH HHS S10 OD018015NIH HHS S10 OD038119NINDS NIH HHS R01 NS121379
Abstract
background
methodsWe used bioinformatic approaches to identify novel
resultsWe identified a well-conserved APA signal downstream of
conclusionsAPA-mediated regulation of
Indexed as
Energy MetabolismMitochondria, HeartMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelAnimalsCells, CulturedGene Knock-In TechniquesHeart FailureHumansMiceMice, Inbred C57BLMice, TransgenicPolyadenylationProtein IsoformsRatsNAV1.5 Voltage-Gated Sodium ChannelProtein IsoformsSCN5A protein, humanScn5a protein, mouseScn5a protein, rataction potentialscardiomyopathy, dilateddefibrillators, implantablemitochondriasodium channels
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.