Evidence map›Paper›PMID 41808585›Full record

ArticleJournal of neuroendocrinology2026

Effects of gonadectomy on brain sex hormone levels and amyloid pathology in male and female App

Patricia Muñoz, Heba G Ali, Aphrodite Demetriou, Maria Latorre-Leal, Makoto Shimozawa, Ljerka Delac, Tudor-Fabian Troncea-Sandu, Jose Inzunza, Per Nilsson, Silvia Maioli and 1 more

Abstract read
In one paragraph

Article in Journal of neuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Patricia MuñozDivision of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Heba G AliDivision of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Aphrodite DemetriouDivision of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Maria Latorre-LealDivision of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Makoto ShimozawaDivision of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.ORCID https://orcid.org/0000-0001-9618-0533
Ljerka DelacDivision of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.ORCID https://orcid.org/0000-0003-1840-1710
Tudor-Fabian Troncea-SanduDivision of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Jose InzunzaDepartment of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.
Per NilssonDivision of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Silvia MaioliDivision of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Ivan NalvarteDivision of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.ORCID https://orcid.org/0000-0001-6828-2583

Funding

Understanding the role of menopause and estrogen receptor activation for Alzheimer's disease riskR01AG065209 · NIA · KAROLINSKA INSTITUTE · PI NALVARTE, IVAN · 2020 to 2023
$1.8M
Alzheimerfonden AF-1031993Demensfonden DF-1031918Egyptian Cultural and Educational BureauNIA NIH HHS R01AG065209Vetenskapsrådet 2023-02366
6 · The paper itself

Abstract

More women than men are diagnosed with Alzheimer's disease (AD). Sex hormones have been ascribed neuroprotective properties, and their decline, particularly the reduction of estrogen during menopause, has been implicated in AD risk. In this study, we examined how loss of circulating sex hormones affects cognitive performance and amyloid pathology in two mouse models of AD, the aggressive App

Indexed as

Alzheimer DiseaseAmyloidosisBrainGonadal Steroid HormonesTestosteroneAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsDisease Models, AnimalEstrogensFemaleMaleMiceMice, TransgenicOrchiectomyOvariectomyAmyloid beta-PeptidesAmyloid beta-Protein PrecursorEstrogensGonadal Steroid HormonesTestosteroneAlzheimer's diseasegonadectomyIGF‐1menopausesex hormones

Identifiers

PMID41808585
PMCPMC12976827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.