Evidence map›Paper›PMID 41808523›Full record

ArticlePhysiological reports2026

Genetic deletion of ASIC3 alters left ventricular remodeling and autonomic function after myocardial infarction in mice.

Karley M Monaghan, David D Gibbons, Chad C Ward, Maram El-Geneidy, William J Kutschke, Kathy A Zimmerman, Donald A Morgan, Harald M Stauss, Anne Marie S Harding, Michelle C M Bader and 5 more

Abstract read
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Karley M MonaghanDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0002-5479-4024
David D GibbonsDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Chad C WardDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Maram El-GeneidyDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
William J KutschkeDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Kathy A ZimmermanDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Donald A MorganDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Harald M StaussDepartment of Health, Sport, and Human Physiology, University of Iowa, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0001-6647-1903
Anne Marie S HardingDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Michelle C M BaderDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Peter M SnyderDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Rasna SabharwalDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Robert M WeissDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Kamal RahmouniDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Christopher J BensonDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0001-6600-8193

Funding

Role of FGF21 Action in Hypothalamic Neurons in Obesity-Associated HypertensionR01HL162773 · NHLBI · UNIVERSITY OF IOWA · PI KAMAL RAHMOUNI · 2023 to 2026
$2.4M
Propagation and Resolution of Injury in Calcific Aortic Valve DiseaseR01HL142935 · NHLBI · UNIVERSITY OF IOWA · PI WEISS, ROBERT M · 2018 to 2022
$2.3M
Stress-induced cardiovascular dysfunction in dilated cardiomyopathyR01HL149677 · NHLBI · UNIVERSITY OF IOWA · PI SABHARWAL, RASNA · 2020 to 2023
$2.1M
Hydrogel matrices to study the role of inflammation and biological sex on aortic valve fibrocalcificationR01HL171197 · NHLBI · UNIVERSITY OF COLORADO · PI KRISTI S. ANSETH, ROBERT M WEISS · 2024 to 2026
$2.0M
Neuronal Cilia in HypertensionR01HL172944 · NHLBI · UNIVERSITY OF IOWA · PI KAMAL RAHMOUNI · 2025 to 2026
$1.4M
RAS-Driven Central Inflammation and Cognitive Decline with Aging.R21AG070188 · NIA · UNIVERSITY OF IOWA · PI SABHARWAL, RASNA · 2021 to 2022
$425k
High Resolution Research UltrasoundS10OD038119 · OD · UNIVERSITY OF IOWA · PI WEISS, ROBERT M · 2025 to 2025
$419k
BLRD VA I01 BX000776BLRD VA I01 BX004249BLRD VA IK6 BX006040HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL142935HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL149677HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL162773HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL171197HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL172944HHS | NIH | National Institute on Aging (NIA) R21AG070188HHS | NIH | NIH Office of the Director (OD) S10OD038119NHLBI NIH HHS R01 HL142935NHLBI NIH HHS R01 HL149677NHLBI NIH HHS R01 HL162773NHLBI NIH HHS R01 HL171197NHLBI NIH HHS R01 HL172944NIA NIH HHS R21 AG070188NIH HHS S10 OD038119U.S. Department of Veterans Affairs (VA) 5I01BX000776U.S. Department of Veterans Affairs (VA) I01BX004249U.S. Department of Veterans Affairs (VA) IK6BX006040
6 · The paper itself

Abstract

Cardiac afferent neurons have been shown to trigger overactivation of neurohormonal systems known to drive adverse cardiac remodeling following myocardial infarction (MI). Acid-sensing ion channels (ASICs) that are highly expressed in cardiac sympathetic afferents sense ischemia-induced myocardial acidosis. We hypothesized that genetic deletion of ASICs might abrogate disadvantageous remodeling after MI by disrupting afferent signaling pathways otherwise resulting in overactivation of neurohormonal responses. To test this, we induced MI in wild type (WT) and ASIC3

Indexed as

Acid Sensing Ion ChannelsMyocardial InfarctionVentricular RemodelingAnimalsBaroreflexBlood PressureHeart RateMaleMiceMice, Inbred C57BLMice, KnockoutAcid Sensing Ion ChannelsASIC3 protein, mousecardiac hypertrophyischemic heart diseaseneurohormonal activation

Identifiers

PMID41808523
PMCPMC12976581

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.