ArticleNursing in critical care2026
Risk Factors for Antibiotic-Associated Diarrhoea in Paediatric Patients With Severe Pneumonia: A Retrospective Cohort.
Article in Nursing in critical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Insights into the mechanism of intestinal flora imbalance and immune disorder in co-morbidity of pneumonia and diarrhea in children.Frontiers in pediatrics · 2026Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere pneumonia in paediatric patients typically necessitates prolonged courses of antibiotic therapy, a practice that elevates vulnerability to antibiotic-associated diarrhoea (AAD).
aimThe present study aimed to evaluate the clinical profiles of paediatric patients with AAD secondary to severe pneumonia and to explore evidence-based nursing interventions for this complication. STUDY
designA retrospective cohort. This study was conducted at a tertiary hospital in China, enrolling paediatric patients diagnosed with severe pneumonia. To identify independent risk factors for AAD development, a stepwise analytical framework was applied, comprising univariate analysis, correlation analysis and multivariate logistic regression modelling.
resultsA total of 306 children with severe pneumonia were included. The overall incidence of secondary AAD among this cohort was 13.73% (42/306). The median time from antibiotic initiation to AAD onset was 5 days (IQR 3-8 days). Multivariate logistic regression analysis identified five independent risk factors for AAD: age < 1 year (odds ratio [OR] = 2.246, 95% confidence interval [CI]: 1.821-2.909), administration of penicillin-class antibiotics (OR = 2.474, 95% CI: 2.043-3.061), antibiotic treatment duration ≥ 1 week (OR = 2.970, 95% CI: 2.127-3.507), requirement for mechanical ventilation (OR = 3.049, 95% CI: 2.895-3.725), and hospital stay > 14 days (OR = 1.954, 95% CI: 1.630-2.402). In contrast, prophylactic probiotic administration was identified as a protective factor against AAD (OR = 0.801, 95% CI: 0.586-0.944).
conclusionsIn clinical practice, stratified management protocols should be implemented for paediatric populations at high risk of AAD. RELEVANCE TO CLINICAL PRACTICE: Core components of such protocols include optimising antibiotic selection and treatment duration, initiating early combined probiotic interventions and enhancing intestinal function monitoring.
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