Evidence map›Paper›PMID 41808271›Full record

ReviewExpert opinion on drug discovery2026

The latest

Lauren A Dalvin, Stephanie D Burr, Hien Ong, James A Armitage

Abstract readReview
In one paragraph

Review in Expert opinion on drug discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lauren A DalvinDepartment of Ophthalmology and Medical Oncology, Mayo Clinic, Rochester, MN, USA.
Stephanie D BurrDepartment of Ophthalmology and Medical Oncology, Mayo Clinic, Rochester, MN, USA.
Hien OngDepartment of Ophthalmology and Medical Oncology, Mayo Clinic, Rochester, MN, USA.
James A ArmitageSchool of Medicine, Deakin University, Geelong, Australia.

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3M
Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
Institutional Career Development CoreKL2TR002379 · NCATS · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2017 to 2026
$14.9M
NCATS NIH HHS KL2 TR002379NCATS NIH HHS UL1 TR002377NCI NIH HHS P30 CA015083
6 · The paper itself

Abstract

introductionUveal melanoma (UM) is the most common primary intraocular malignancy in adults, but primary tumor treatment carries a high risk of permanent vision loss and does not adequately prevent metastatic progression. AREAS COVERED: This review covers current and emerging EXPERT OPINION: While traditional cell lines have provided an important foundation for UM research, emerging spheroid and patient-derived organoid models may more accurately represent in vivo tumor behavior and the tumor microenvironment. Pairing these 3D models with co-culture techniques could dramatically improve the representativeness of UM models. Researchers should consider testing promising therapeutics on a panel of models representing different UM subtypes, with particular attention to high-risk UM, such as those with BAP1 loss.

Indexed as

Antineoplastic AgentsDrug DiscoveryMelanomaModels, BiologicalUveal NeoplasmsAnimalsCell Line, TumorCoculture TechniquesHumansOrganoidsSpheroids, CellularUveal MelanomaAntineoplastic AgentsCell linesco-culture systemsin vitro modelsisogenic cell linespatient-derived organoidsprecision medicinespheroidsuveal melanoma

Identifiers

PMID41808271
PMCPMC13010537

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.