Evidence map›Paper›PMID 41808158›Full record

ArticleInfectious agents and cancer2026

Dengue virus infection and potential association with acute lymphoblastic leukemia in Egypt: a pilot study.

Lamiaa Fadel Alkilany, Shaza Fadel Alkilany, Azza Shibl, Doaa A Mohammed, Mayada Fawzy Sedik, Hyam H Mahran, Yomna R Mahboub, Hany K Soliman, Aliaa M A Ghandour

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Article in Infectious agents and cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Lamiaa Fadel AlkilanyVirology and Immunology Unit, Cancer Biology Department, South Egypt Cancer Institute, Assiut University, Assiut, 71515, Egypt. lam.yaa93@yahoo.com.ORCID http://orcid.org/0000-0002-3356-9119
Shaza Fadel AlkilanyPublic Health and Community Medicine Department, Faculty of Medicine, Minia University, Minia, Egypt.
Azza ShiblPediatric Oncology and Hematological Malignancy Department South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Doaa A MohammedClinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Mayada Fawzy SedikMedical Oncology and Malignant Hematology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Hyam H MahranPediatric Department, Assuit University Hospitals, Assiut, Egypt.
Yomna R MahboubClinical Hematology and Internal Medicine Department, Assuit University Hospitals, Assiut, Egypt.
Hany K SolimanVirology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Aliaa M A GhandourMedical Microbiology and Immunology Department, Faculty of Medicine, Assuit University, Assiut, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDengue fever is arthropod born disease transmitted by the bite of a mosquito called Aedes aegypti. Some researchers have suggested a link between previous dengue infection and leukemia. The aim of this pilot study is to determine the frequency of dengue infection in acute lymphoblastic leukemia patients (ALL) compared to age and sex matched controls and to find the impact of this infection on the disease outcome. PATIENTS AND

methodsThis is a single center pilot study that included two groups, 30 newly diagnosed pediatric ALL patients and 22 newly diagnosed adult ALL patients that were compared with 50 age and sex matched healthy controls (25 for each group) and 8 pediatric immunosuppressed controls. ELISA was used to detect IgM and IgG antibodies in serum samples at presentation and clinical and laboratory data at admission were collected. Positive and negative dengue patients were followed up for a minimum of six months (hybrid case control –cohort study).

resultsAmong pediatric patients who were evaluated for dengue infection by the serological tests, 46.7% (14/30), 8% (2/25) and 0% (0/8) tested positive for IgG in patients, immuno-competent and immunocompromised controls respectively (p value 0.002). There was a significant association between acute dengue infection and BCR-ABL fusion oncogenic gene only in pediatric patients. No statistically significant difference in short term outcomes was observed.

conclusionThis pilot study provides preliminary data to guide large scale research on the role of dengue infection as a predisposing or exacerbating factor in genetically susceptible children.

Indexed as

BCR-ABLDengueFusionGeneLeukemiaLymphoblasticPilot

Identifiers

PMID41808158
PMCPMC13036980

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