Safety and efficacy of the polymer enhanced AS-ELARIS

Isabel Heel, Agnieszka A Karol, Peter W M Kronen, Brigitte von Rechenberg, Karina Klein

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Article in Journal of orthopaedic surgery and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Isabel HeelMusculoskeletal Research Unit (MSRU), University of Zurich, Strickhofstrasse 40a, 8057, Zurich, Switzerland.

Agnieszka A KarolMusculoskeletal Research Unit (MSRU), University of Zurich, Strickhofstrasse 40a, 8057, Zurich, Switzerland.

Peter W M KronenMusculoskeletal Research Unit (MSRU), University of Zurich, Strickhofstrasse 40a, 8057, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-7689-7534

Brigitte von RechenbergMusculoskeletal Research Unit (MSRU), University of Zurich, Strickhofstrasse 40a, 8057, Zurich, Switzerland.

Karina KleinMusculoskeletal Research Unit (MSRU), University of Zurich, Strickhofstrasse 40a, 8057, Zurich, Switzerland. kklein@vetclinics.uzh.ch.ORCID http://orcid.org/0000-0002-6878-5583

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLumbar fusion surgery using pedicle screws and intervertebral cages is frequently performed to treat low back pain when conservative therapies were unsuccessful. Screw loosening, however, remains one of the most common postoperative complications. The purpose of this study was to show that the fixation with polymer-enhanced AS-ELARIS

methodsForty adult female sheep were enrolled in the study and posterolateral fusions were performed at two non-adjacent lumbar levels (L1+L2, L4+L5), implanting eight AS-ELARIS

resultsDespite surgical challenges in achieving optimal screw positioning, all evaluations demonstrated good biocompatibility and progressive osseointegration. Ultrasonic liquefaction-mediated polymer enhancement proved safe at all investigated timepoints, without evidence of thermal or inflammatory tissue damage.

conclusionsThe AS-ELARIS

Indexed as

Lumbar VertebraePedicle ScrewsPolyestersSpinal FusionAnimalsFemaleSheepTime FactorsTreatment OutcomePolyesterspoly(lactide)Animal modelAS-ELARIS® pedicle screw systemBiocompatibilityPolylactide polymerSpinal fixationUltrasonic liquefaction

Identifiers

PMID41808141

DOI10.1186/s13018-026-06773-9

PMCPMC13088813

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.