Evidence map›Paper›PMID 41808065›Full record

SynthesisBMC surgery2026

Laparoscopic adhesiolysis for adhesion-related chronic abdominal and pelvic pain after gynaecological and general surgery: an updated meta-analysis and systematic review.

Mengdie Wang, Xin Guo, Yan Guo, Shiqin Lu, Rui Zhang, Xuesong Chen, Xiaorong Liu, Yali Zhou, Meixian Hu, Zhimei Xu and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mengdie Wang *Faculty of Life Science and Technology, The affliated Anning First People's Hospital, Kunming University of Science and Technology, Kunming, 650302, China.
Xin Guo *Faculty of Life Science and Technology, The affliated Anning First People's Hospital, Kunming University of Science and Technology, Kunming, 650302, China.
Yan Guo *Department of Reproductive Gynecology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, China.
Shiqin LuSchool of Basic Medical Science, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China.
Rui ZhangFaculty of Life Science and Technology, The affliated Anning First People's Hospital, Kunming University of Science and Technology, Kunming, 650302, China.
Xuesong ChenDepartment of Pain Medicine, The Affiliated Anning First People's Hospital of Kunming University of Science and Technology, No. 2, Ganghe South Road, Anning City, Kunming, Yunnan Province, 650302, China.
Xiaorong LiuDepartment of Pain Medicine, The Affiliated Anning First People's Hospital of Kunming University of Science and Technology, No. 2, Ganghe South Road, Anning City, Kunming, Yunnan Province, 650302, China.
Yali ZhouFaculty of Life Science and Technology, The affliated Anning First People's Hospital, Kunming University of Science and Technology, Kunming, 650302, China.
Meixian HuFaculty of Life Science and Technology, The affliated Anning First People's Hospital, Kunming University of Science and Technology, Kunming, 650302, China.
Zhimei XuFaculty of Life Science and Technology, The affliated Anning First People's Hospital, Kunming University of Science and Technology, Kunming, 650302, China.
Guozhong ZhouSchool of Basic Medical Science, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China. 20220247@kust.edu.cn.ORCID http://orcid.org/0009-0001-9112-6631
Yinghui YuFaculty of Life Science and Technology, The affliated Anning First People's Hospital, Kunming University of Science and Technology, Kunming, 650302, China. yuyinghui6870@163.com.ORCID http://orcid.org/0009-0003-7276-6187

Funding

​Kunming University of Science and Technology ZZ2023YX126A
6 · The paper itself

Abstract

backgroundChronic pain resulting from postoperative adhesions represents a significant clinical concern due to its substantial impact on patient quality of life; however, optimal therapeutic management remains contentious. This systematic review and meta-analysis aimed to evaluate the efficacy of laparoscopic adhesiolysis in alleviating chronic pain attributable to postoperative adhesions, and to assess the influence of adhesion barriers on treatment outcomes.

methodsA comprehensive systematic review was conducted by searching PubMed, Embase, and Web of Science from database inception through August 2025. Studies reporting pain improvement as the primary outcome, along with safety outcomes (including complication incidence and mortality), were eligible for inclusion. Pooled estimates were calculated using a random-effects model, and heterogeneity was quantified employing the I

resultsA total of 30 studies involving 1,450 patients were included in the systematic review. In 27 single-arm observational studies (n = 1,150), laparoscopic adhesiolysis was associated with a pooled pain improvement rate of 67.3% (95% CI 57.5-76.2%), with substantial heterogeneity (I

conclusionAlthough observational studies report relatively high rates of pain improvement, these findings should be interpreted as descriptive and hypothesis-generating. The highest level of available evidence from randomized controlled trials does not demonstrate a clinically meaningful benefit of laparoscopic adhesiolysis over diagnostic laparoscopy alone.

trial registrationPROSPERO CRD42023478049.

Indexed as

Abdominal PainChronic PainGynecologic Surgical ProceduresLaparoscopyPelvic PainPostoperative PainFemaleHumansTissue AdhesionsAdhesion barriersChronic painLaparoscopic adhesiolysisMeta-analysisPain managementPostoperative adhesionsSystematic review

Identifiers

PMID41808065
PMCPMC13088702

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.