Trial reportBMC oral health2026
Comparison of the effect of injectable platelet rich fibrin and advanced platelet rich fibrin with xenograft on the socket preservation of extracted mandibular molars (a randomized controlled clinical trial).
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06936358 (Comparison of the Effect of Injectable Platelet-rich Fibrin and Advanced Platelet-rich Fibrin With Xenograft on the Socket Preservation of Mandibular Extracted Molars), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Effect of Injectable Platelet-rich Fibrin and Advanced Platelet-rich Fibrin With Xenograft on the Socket Preservation of Mandibular Extracted Molars ( a Randomised Controlled Clinical Trial) Comparison of the Effect of Injectable Platelet-rich Fibrin and Advanced Platelet-rich Fibrin With Xenograft on the Socket Preservation of Mandibular Extracted Molars ( a Randomised Controlled Clinical Trial)
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionVarious materials and techniques have been employed for socket preservation to minimize alveolar bone resorption in both horizontal and vertical dimensions, as well as to prevent soft tissue collapse following tooth extraction. Due to the regenerative properties of growth factors and proteins released by platelets, the development and application of platelet-enriched preparations have revolutionized the field of regenerative medicine.
methodsThirty healthy participants with non-restorable mandibular teeth were divided into three groups to compare the effects of injectable platelet-rich fibrin (I-PRF) combined with xenograft, advanced platelet-rich fibrin (A-PRF) mixed with xenograft, and xenograft alone on post-extraction socket healing. Blood samples were centrifuged to prepare the PRF materials, which were applied immediately after tooth extraction along with the bone grafts. Clinical healing was assessed one week post-surgery using a modified healing index, while bone density and height were evaluated through standardized radiographs and CBCT scans immediately postoperatively and at intervals up to twelve weeks. Bone density was quantitatively analyzed using ImageJ software by segmenting the socket into specific regions and normalizing the values against background and healthy bone. Bone height measurements were standardized and adjusted to ensure accuracy.
resultsClinical results demonstrated significant improvements in healing across all three groups. At the first week, 50% of patients in Group A and 40% in Group B showed healing, with 100% healing observed in all groups by the fourth week. Bone density measurements revealed significant differences between groups at each follow-up point, with Group B exhibiting the highest mean bone density at the first week, followed by Group A and then Group C. Bone height loss also differed significantly among groups throughout the follow-up period, with Group C experiencing the greatest bone height loss, followed by Group B and then Group A.
conclusionThis study demonstrates that both A-PRF and I-PRF, when combined with xenograft, significantly enhance the healing process and increase bone density in socket preservation following mandibular molar extraction, outperforming the control group treated with xenograft alone. TRIAL REGISTRATION: The current study was registered retrospectively at ClinicalTrials.gov (Registration ID: NCT06936358, Date: April 20, 2025).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.