Evidence map›Paper›PMID 41807952›Full record

ArticleBMC veterinary research2026

The comparison of acute phase proteins in experimentally induced canine acute pancreatitis.

Eszter Tünde Kanyorszky, Ágnes Sterczer, Zsuzsanna Vizi, Emma Léda Babits, Nándor Balogh, Katalin Lányi, Ferenc Manczur

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Eszter Tünde KanyorszkyDepartment of Internal Medicine, University of Veterinary Medicine Budapest, István utca 2, Budapest, 1078, Hungary.
Ágnes SterczerDepartment of Internal Medicine, University of Veterinary Medicine Budapest, István utca 2, Budapest, 1078, Hungary. sterczer.agnes@univet.hu.
Zsuzsanna ViziDepartment of Internal Medicine, University of Veterinary Medicine Budapest, István utca 2, Budapest, 1078, Hungary.
Emma Léda BabitsDepartment of Internal Medicine, University of Veterinary Medicine Budapest, István utca 2, Budapest, 1078, Hungary.
Nándor BaloghPraxislab Kft, Iskola u. 3, Budapest, 1038, Hungary.
Katalin LányiDepartment of Food Hygiene, University of Veterinary Medicine Budapest, István utca 2, Budapest, 1078, Hungary.
Ferenc ManczurDepartment of Internal Medicine, University of Veterinary Medicine Budapest, István utca 2, Budapest, 1078, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute pancreatitis triggers the production of acute-phase proteins (APPs) in the body, among which C-reactive protein (CRP) is the most extensively studied and widely used for both diagnosis and prognosis. The diagnostic value of other APPs is less well known. Our study aimed to compare six APPs in a canine model of experimentally induced acute pancreatitis (AP). We measured serum CRP, serum amyloid A (SAA), haptoglobin (HAPT), hepcidin-α and -ß (HEPC-α, HEPC-ß), and albumin (ALB) levels in 10 dogs over 8 consecutive days following AP induction with cerulein injections.

resultsDuring the study, CRP was the most consistent marker for tracking temporal changes in pancreatic enzymes among the studied APPs. We found no correlation between pancreatic enzymes and CRP or SAA levels; however, a significant positive correlation was observed between CRP and SAA. A moderate correlation was identified between serum cholesterol levels and both CRP and SAA concentrations. Albumin exhibited a moderate negative correlation with CRP and SAA. Neither HAPT nor hepcidins correlated with CRP, SAA, or pancreatic enzymes. Serum albumin remained within the reference interval.

conclusionsBased on our experimental results, CRP remains the most consistent APP for monitoring canine pancreatitis. Our findings did not support the practical usefulness of hepcidins or haptoglobin in tracking pancreatitis in dogs.

Indexed as

Acute-Phase ProteinsDog DiseasesPancreatitisAcute DiseaseAnimalsBiomarkersCeruletideC-Reactive ProteinDogsFemaleHaptoglobinsHepcidinsMaleSerum AlbuminSerum Amyloid A ProteinAcute-Phase ProteinsBiomarkersCeruletideC-Reactive ProteinHaptoglobinsHepcidinsSerum AlbuminSerum Amyloid A ProteinAcute phase proteinsAlbuminCanine pancreatitisC-reactive proteinExperimental acute pancreatitisHaptoglobinHepcidinSerum amyloid A

Identifiers

PMID41807952
PMCPMC13085582

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