ReviewInflammopharmacology2026
Trehalose as an anti-inflammatory agent: insights into molecular mechanisms and therapeutic applications.
Review in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Inflammation is an important biological process, involving a cascade of molecular events in response to pathogenic triggers and plays a key role in the pathogenesis of many diseases. Trehalose, a natural disaccharide, exhibits strong anti-inflammatory properties. It has shown cytoprotective effects in multiple in vitro and in vivo models of inflammation-related disorders, including atherosclerosis, osteoarthritis, neurodegenerative diseases, and metabolic diseases. Trehalose mediates its anti-inflammatory effects by regulating key molecular pathways, including nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and Janus kinase (JAK)-signal transducer and activator of transcription (STAT), as well as through regulation of oxidative stress, cellular homeostasis, and enhancement of autophagy. This review aims to summarize the underlying mechanisms by which trehalose influences the inflammatory response in various systems.
Indexed as
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41807879What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.