Evidence map›Paper›PMID 41807832›Full record

ArticleNature chemical biology2026

Structures of ALG3/9/12 reveal the assembly logic of the N-glycan oligomannose core.

J Andrew N Alexander, Shu-Yu Chen, Somnath Mukherjee, Mario de Capitani, Rossitza N Irobalieva, Lorenzo Rossi, Parth Agrawal, Julia Kowal, Matheus A Meirelles, Markus Aebi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

J Andrew N AlexanderInstitute of Molecular Biology and Biophysics, Eidgenössische Technische Hochschule (ETH) Zürich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-8759-1389
Shu-Yu ChenDepartment of Chemistry and Applied Biosciences, Eidgenössische Technische Hochschule (ETH) Zürich, Zurich, Switzerland.
Somnath MukherjeeDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5447-4496
Mario de CapitaniDepartment of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0003-0187-6277
Rossitza N IrobalievaInstitute of Molecular Biology and Biophysics, Eidgenössische Technische Hochschule (ETH) Zürich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-3540-4294
Lorenzo RossiInstitute of Molecular Biology and Biophysics, Eidgenössische Technische Hochschule (ETH) Zürich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-6051-3260
Parth AgrawalDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Julia KowalInstitute of Molecular Biology and Biophysics, Eidgenössische Technische Hochschule (ETH) Zürich, Zurich, Switzerland.
Matheus A MeirellesDepartment of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-2097-4270
Markus AebiInstitute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Zurich, Switzerland.
Jean-Louis ReymondDepartment of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0003-2724-2942
Anthony A KossiakoffDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-3174-9359
Sereina RinikerDepartment of Chemistry and Applied Biosciences, Eidgenössische Technische Hochschule (ETH) Zürich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-1893-4031
Kaspar P LocherInstitute of Molecular Biology and Biophysics, Eidgenössische Technische Hochschule (ETH) Zürich, Zurich, Switzerland. locher@mol.biol.ethz.ch.ORCID http://orcid.org/0000-0002-8207-2889

Funding

Chaperone-Assisted Structure Determination of Membrane ProteinsR01GM117372 · NIGMS · UNIVERSITY OF CHICAGO · PI ANTHONY A KOSSIAKOFF · 2016 to 2026
$4.0M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) GM117372NIGMS NIH HHS R01 GM117372Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_196862Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 315230_220007
6 · The paper itself

Abstract

Asparagine-linked glycans are essential for the maturation and function of most eukaryotic secretory proteins. The biosynthesis and transfer of dolichylpyrophosphate-anchored GlcNAc

Indexed as

MannoseMannosyltransferasesOligosaccharidesPolysaccharidesCryoelectron MicroscopyEndoplasmic ReticulumGlycosylationMolecular Dynamics SimulationMannoseMannosyltransferasesOligosaccharidesPolysaccharides

Identifiers

PMID41807832
PMCPMC13503287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.