Evidence map›Paper›PMID 41807821›Full record

Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

In vivo assessment of Berger's space in primary angle closure disease using AS-OCT: a comparative study.

Siyi Tan, Dongjun Li, Dianfeng Liu, Weiqi Wang, Wenjun He, Bingsong Wang

Abstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Siyi TanBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China.
Dongjun LiBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China.
Dianfeng LiuBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China.
Weiqi WangBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China.
Wenjun HeBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China.
Bingsong WangBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China. wbsod@sina.com.ORCID http://orcid.org/0000-0003-1622-1257

Funding

Natural Science Foundation of Beijing Municipality 7202030
6 · The paper itself

Abstract

purposeTo observe Berger's space in vivo in eyes with primary angle closure disease (PACD) and to identify factors associated with its visibility.

methodsThis cross-sectional observational study was conducted at a tertiary center and included 81 participants (109 eyes) diagnosed with PACD. Anterior segment optical coherence tomography (AS-OCT, CASIA2) images were used to evaluate the visibility of the Berger's space, and ocular biometric parameters were measured. The visibility of the Berger's space was compared among acute primary angle closure (APAC), fellow eyes of APAC (F-APAC), and chronic primary angle closure (glaucoma) (CPAC[G]). Additionally, ocular biometric parameters were compared between groups with visible and invisible Berger's space, and generalized estimating equations (GEEs) were employed in the regression analysis to account for inter-eye correlations.

resultsThe APAC group exhibited the highest prevalence of visible Berger's space at 36.67%, which was significantly greater than the rates of 9.38% in the F-APAC group and 17.02% in the CPAC(G) group (p = 0.028). The visible Berger's space group was younger (p = 0.008) with narrower anterior chamber angle, and anteriorly shifted lens position (p = 0.031) compared to the invisible Berger's space group. Factors associated with visible Berger's space included acute angle closure (p = 0.017, odds ratio = 5.650, 95% CI: 1.325-24.084) and younger age (p = 0.017, odds ratio = 0.937, 95% CI: 0.889-0.989).

conclusionAcute angle closure and younger age were both associated with higher visibility of the Berger's space. Eyes with visible Berger's space are younger, have narrower anterior chamber angles and more anteriorly shifted lens positions.

Indexed as

Anterior Eye SegmentGlaucoma, Angle-ClosureIntraocular PressureTomography, Optical CoherenceAgedCross-Sectional StudiesFemaleGonioscopyHumansMaleMiddle AgedBerger’s spaceBiometric parametersPrimary angle closure disease

Identifiers

PMID41807821
PMCPMC13341890

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.