Evidence map›Paper›PMID 41807785›Full record

ArticleArchives of toxicology2026

Characterization and quantitation of urinary metabolites of 3-monochloropropane-1,2-diol (3-MCPD) in rats.

Thorsten Henning, Cornelius Goerdeler, Ahmed H El-Khatib, Klas Meyer, Gustav G Bruer, Klaus Abraham, Bernhard H Monien

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thorsten HenningGerman Federal Institute for Risk Assessment (BfR), Food and Feed Safety in the Food Chain, Max-Dohrn-Strasse 8-10, 10589, Berlin, Germany.ORCID 0000-0001-6696-9277
Cornelius GoerdelerGerman Federal Institute for Risk Assessment (BfR), Food and Feed Safety in the Food Chain, Max-Dohrn-Strasse 8-10, 10589, Berlin, Germany.ORCID 0000-0002-6422-4738
Ahmed H El-KhatibGerman Federal Institute for Risk Assessment (BfR), Reference Center Food and Feed Analysis, 10589, Berlin, Germany.ORCID 0000-0002-2012-5893
Klas MeyerAnalytical Chemistry, Federal Institute for Materials Research and Testing (BAM), 12489, Berlin, Germany.ORCID 0000-0003-1837-3801
Gustav G BruerFraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625, Hannover, Germany.ORCID 0000-0002-9712-8187
Klaus AbrahamGerman Federal Institute for Risk Assessment (BfR), Food and Feed Safety in the Food Chain, Max-Dohrn-Strasse 8-10, 10589, Berlin, Germany.ORCID 0000-0003-1895-9909
Bernhard H MonienGerman Federal Institute for Risk Assessment (BfR), Food and Feed Safety in the Food Chain, Max-Dohrn-Strasse 8-10, 10589, Berlin, Germany. bernhard.monien@bfr.bund.de.ORCID 0000-0003-1561-2352

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatty acid esters of 3-monochloropropane-1,2-diol (3-MCPD) are heat-induced contaminants formed from fats and sodium chloride. The mode of action for the 3-MCPD mediated induction of renal tubule neoplasms in rats is still unclear, which is in part due to lacking metabolism data. In the current study, urinary metabolites were identified by one- and two-dimensional

Indexed as

alpha-ChlorohydrinAdministration, OralAnimalsFemaleMagnetic Resonance SpectroscopyMaleMass SpectrometryRatsRats, Sprague-Dawleyalpha-Chlorohydrin3-MCPD3-Monochloropropane-1,2-diolMetabolismThiodiglycolic acidUrine

Identifiers

PMID41807785
PMCPMC13221421

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.