Evidence map›Paper›PMID 41807774›Full record

ArticleOdontology2026

Physicochemical properties, biological activity, and anti-cariogenic potential of a novel sodium fluoride-chitosan gel.

Ranam Moreira Reis, Ângelo Márcio Leite Denadai, Wesley William Gonçalves Nascimento, Jeferson Gomes da Silva, Aline Rogéria Freire de Castilho, Sandra Bertelli Ribeiro de Castro, Eliseu Aldrighi Munchow, Regina Maria Puppin-Rontani, Fabiola Galbiatti de Carvalho

Abstract read
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In one paragraph

Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ranam Moreira ReisGraduate Program of Applied Health Sciences, Universidade Federal de Juiz de Fora-Governador Valadares Campus, Governador Valadares, Minas Gerais, Brazil.ORCID http://orcid.org/0000-0001-8001-5541
Ângelo Márcio Leite DenadaiDepartment of Pharmacy, Universidade Federal de Juiz de Fora-Governador Valadares Campus, Governador Valadares, Minas Gerais, Brazil.ORCID http://orcid.org/0000-0001-8259-6933
Wesley William Gonçalves NascimentoDepartment of Pharmacy, Universidade Federal de Juiz de Fora-Governador Valadares Campus, Governador Valadares, Minas Gerais, Brazil.ORCID http://orcid.org/0000-0001-6475-7625
Jeferson Gomes da SilvaDepartment of Pharmacy, Universidade Federal de Juiz de Fora-Governador Valadares Campus, Governador Valadares, Minas Gerais, Brazil.ORCID http://orcid.org/0000-0002-4219-1437
Aline Rogéria Freire de CastilhoDepartment of Pediatric Dentistry, Indiana University School of Dentistry, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-4704-6973
Sandra Bertelli Ribeiro de CastroFaculty of Medicine of Mucuri, Universidade Federal Dos Vales Do Jequitinhonha E Mucuri, Teófilo Otoni, Minas Gerais, Brazil.ORCID http://orcid.org/0000-0002-5535-0919
Eliseu Aldrighi MunchowGraduate Program of Dentistry, School of Dentistry, Federal University of Rio Grande Do Sul, Porto Alegre, Brazil.ORCID http://orcid.org/0000-0002-6925-0097
Regina Maria Puppin-RontaniDepartamento de Saúde Coletiva, Odontopediatria E Ortodontia, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-1218-5159
Fabiola Galbiatti de CarvalhoFaculty of Dentistry, Department of Pediatric Dentistry, Federal University of Uberlândia, Campus Umuarama, Bloco UMU2G Av. Pará, 1720, Bairro Umuarama, Uberlândia, Minas Gerais, Brazil. fabiola.carlo@ufu.br.ORCID http://orcid.org/0000-0003-2510-1329

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 308278/2020-8Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-02052-21Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-02506-22Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ 02762/25Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-02895-2
6 · The paper itself

Abstract

This study evaluated the effects of a sodium fluoride-chitosan (NaF/Chit) gel without a crosslinker on Streptococcus mutans biofilm, enamel demineralization, and cell viability. The synthesized 5.6% NaF/Chit gel was characterized by rheological tests (steady and oscillatory shear tests and viscosity), Electrical Impedance Spectroscopy (EIS) to measure impedance modulus, real and imaginary components, admittance, and ion dissociation and Fourier Transform Infrared Spectroscopy (FTIR). Enamel blocks were prepared and assigned to five groups (n = 5): 2.8% Chit, 2.8% NaF, 5.6% NaF/Chit, 1.23% commercial acidulated phosphate fluoride (APF) (positive control), and acetic acid (negative control). S. mutans biofilm were grown for 48 h with daily 1-min applications of each group. The colony-forming units (CFU/mL) and the change in the surface Knoop hardness percentage (%KHN) were assessed before and after biofilm growth. Cytotoxicity was tested using RAW 264.7 cells (MTT assay). The 5.6% NaF/Chit gel showed a rigid and thixotropic profile and higher viscosity than the 2.8% Chit gel. EIS confirmed the ion release of Na

Indexed as

ChitosanDental cariesRheologySodium fluorideStreptococcus mutans

Identifiers

PMID41807774

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.