Evidence map›Paper›PMID 41807758›Full record

ReviewNature reviews. Cardiology2026

Antiphospholipid antibodies and cardiovascular thrombosis.

Sina Rashedi, Hannah Leyva, Saman A Siddiqui, Syed Bukhari, Mariana B Pfeferman, Nathan W Watson, Francisco Ujueta, Mehrdad Zarghami, Bassil Bacare, Yogendra Kanthi and 25 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Sina RashediDivision of Cardiovascular Medicine, Brigham and Women's Hospital and Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0146-5611
Hannah LeyvaDivision of Cardiovascular Medicine, Brigham and Women's Hospital and Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Saman A SiddiquiBaim Institute for Clinical Research, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1009-4800
Syed BukhariDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Mariana B PfefermanDivision of Cardiovascular Medicine, Brigham and Women's Hospital and Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Nathan W WatsonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Francisco UjuetaDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Mehrdad ZarghamiJamaica Hospital Medical Center, Queens, NY, USA.
Bassil BacareDivision of Cardiovascular Medicine, Brigham and Women's Hospital and Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Yogendra KanthiSection of Vascular Thrombosis & Inflammation, Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-5660-5194
David JimenezRespiratory Department, Hospital Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.ORCID http://orcid.org/0000-0002-4571-7721
Manuel MonrealCátedra de Enfermedad Tromboembólica, Universidad Católica San Antonio de Murcia, Murcia, Spain.ORCID http://orcid.org/0000-0002-0494-0767
Deborah M SiegalDivision of Hematology, Department of Medicine and Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.ORCID http://orcid.org/0000-0003-3806-3245
Geoffrey D BarnesDivision of Cardiovascular Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6532-8440
John W EikelboomDepartment of Medicine, Population Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-4126-1285
Michelle L O'DonoghueTIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Christian T RuffTIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Mattia GalliDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Brittany N WeberDivision of Cardiovascular Medicine, Brigham and Women's Hospital and Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Samuel Z GoldhaberDivision of Cardiovascular Medicine, Brigham and Women's Hospital and Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Sacha UljonDepartment of Pathology, Massachusetts General Hospital, Mass General Brigham, Boston, MA, USA.
Saskia MiddeldorpDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands.ORCID http://orcid.org/0000-0002-1006-6420
Renato D LopesDepartment of Cardiology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0003-2999-4961
David A GarciaDivision of Hematology, Department of Medicine, University of Washington, Seattle, WA, USA.
Gregory Y H LipLiverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, UK.ORCID http://orcid.org/0000-0002-7566-1626
Jeffery I WeitzThrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Jean M ConnorsHematology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Harlan M KrumholzYNHH/Yale Center for Outcomes Research and Evaluation (CORE), New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2046-127X
Jason S KnightDivision of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-0995-9771
Giuseppe LippiSection of Clinical Biochemistry, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0001-9523-9054
Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0003-2562-1156
Mary CushmanDivision of Hematology and Oncology, Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.ORCID http://orcid.org/0000-0002-7871-6143
Karen H CostenbaderDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8972-9388
Gregory PiazzaDivision of Cardiovascular Medicine, Brigham and Women's Hospital and Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Behnood BikdeliDivision of Cardiovascular Medicine, Brigham and Women's Hospital and Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA. bbikdeli@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-1428-879X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antiphospholipid antibodies (aPL) are directed against phospholipids and phospholipid-binding proteins. Laboratory assays used to detect aPL include serological tests for aPL against β

Indexed as

Antibodies, AntiphospholipidAntiphospholipid SyndromeThrombosisBiomarkersHumansRisk FactorsAntibodies, AntiphospholipidBiomarkers

Identifiers

PMID41807758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.