Trial reportSurgical endoscopy2026
Laparoscopic-assisted transversus abdominus plane block versus intraperitoneal irrigation of local anesthetic for patients undergoing laparoscopic cholecystectomy: a prospective, multicentre, single-blinded, randomised controlled trial.
Trial report in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- The Efficacy of Transversus Abdominis Plane Blocks in Roux-en-Y Gastric Bypass - a Systematic Review and Meta-Analysis of Randomised Control Trials.Obesity surgery · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe PROSPECT guidelines provide GRADE A recommendations for paracetamol, non-steroidal anti-inflammatories, and port site infiltration (PSI) with local anaesthetic following laparoscopic cholecystectomy. Despite varying practice, the optimal method of delivering additional local anesthetic is unclear.
aimTo perform a randomised clinical trial (RCT) evaluating the value of laparoscopic-delivered transversus abdominal plane block (L-TAP) compared to intraperitoneal infiltration (IP) in addition to PSI in patients undergoing laparoscopic cholecystectomy.
methodsA multicentre RCT was performed during a 7-month recruitment period (March-October 2025) across 6 hospitals. Patients were randomised on a 1:1 basis to L-TAP or IP. The primary outcome was postoperative visual analogue scores (VAS). Descriptive statistics and regression analyses were performed.
results147 patients were recruited, of whom, 135 underwent final analysis. Of these, 49.6% were allocated to IP (67/135) and 50.1% to L-TAP (68/135). A non-significant difference was observed in baseline clinical information between groups (P > 0.050). A significant reduction in mean VAS was observed in favour of L-TAP at 6-h (IP: 3.3 (standard deviation (SD): 0.3) vs. L-TAP: 2.3 (SD: 0.3), P = 0.014) and 24-h (IP: 3.1 (SD: 0.4) vs. L-TAP: 1.6 (SD: 0.4), P = 0.008), with a trend towards significance at 12-h (IP: 3.5 (SD: 0.4) vs. L-TAP: 2.5 (SD: 0.4), P = 0.063). Moreover, regression analysis demonstrated a significant reduction in VAS following TAP (beta-coefficient: -0.681, standard error: 0.281, P = 0.015), however, a non-significant difference in 'breakthrough' opioid and morphine equivalent consumption was noted between groups (P > 0.050). There was a non-significant difference in surgical data, postoperative outcomes, and quality of life metrics between groups (P > 0.050).
conclusionThis study demonstrates the superiority of L-TAP compared to IP in reducing postoperative pain, as measured VAS scores, in patients undergoing laparoscopic cholecystectomy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.