Evidence map›Paper›PMID 41807660›Full record

ArticleScientific reports2026

Ultrasound-guided skeletal muscle biopsy technique permits measurement of structural, functional, cellular and biochemical properties.

Addison Barber, Amber Willbanks, Guadalupe Meza, Jeremie L A Ferey, Gretchen A Meyer, Sudarshan Dayanidhi, W David Arnold, Richard L Lieber, Ishan Roy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Addison BarberShirley Ryan AbilityLab, 355 E Erie St, Chicago, IL, 60611, USA.
Amber WillbanksShirley Ryan AbilityLab, 355 E Erie St, Chicago, IL, 60611, USA.
Guadalupe MezaShirley Ryan AbilityLab, 355 E Erie St, Chicago, IL, 60611, USA.
Jeremie L A FereyProgram in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA.
Gretchen A MeyerProgram in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA.
Sudarshan DayanidhiShirley Ryan AbilityLab, 355 E Erie St, Chicago, IL, 60611, USA.
W David ArnoldDepartment of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA.
Richard L LieberShirley Ryan AbilityLab, 355 E Erie St, Chicago, IL, 60611, USA.
Ishan RoyShirley Ryan AbilityLab, 355 E Erie St, Chicago, IL, 60611, USA. iroy@sralab.org.

Funding

Muscle Fibrosis in CachexiaK08AR081391 · NIAMS · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI Ishan Roy · 2022 to 2026
$846k
NIAMS NIH HHS K08 AR081391RRD VA IK6 RX003351
6 · The paper itself

Abstract

Human muscle biopsies are often required to study or diagnose diseases. However, traditional approaches are challenging due to limited sample size, quality, or participant discomfort. Fine-gauge needle biopsies (≥ 14-gauge), present an alternative but may yield insufficient tissue for comprehensive analysis. Ultrasound guidance, coupled with vacuum-assisted, single needle-insertion multiple sampling addresses these challenges. In 19 healthy participants (mean age: 30.1 ± 10 years, 42% male), 2-3 samples were collected from a single needle insertion into the vastus lateralis (VL) and tibialis anterior (TA). Summed VL and TA sample masses averaged 148 ± 38 mg and 166 ± 64 mg, with dimensions of 15.83 ± 8 × 2.9 ± 0.6mm

Indexed as

Muscle, SkeletalAdultFemaleHumansMaleUltrasonographyYoung AdultDiagnostic methodsHuman muscle biopsyMuscle imagingTranslational medicine

Identifiers

PMID41807660
PMCPMC13096347

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.