Evidence map›Paper›PMID 41807648›Full record

ArticleNature2026

Alcohol group migration by proximity-enhanced H atom abstraction.

Qian Xu, Yichen Nie, Jacob-Jan Haaksma, Ronghua Zhang, Natalie Holmberg-Douglas, Farid van der Mei, Paul M Scola, Chloe Williams, Jeremiah A Johnson, Alison E Wendlandt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Alkyl-to-Alkyl Palladium Migration Enables Remote C-C Bond Formation.Journal of the American Chemical Society · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qian Xu *Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Yichen Nie *Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jacob-Jan HaaksmaStratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands.ORCID 0009-0006-3663-7179
Ronghua ZhangDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Natalie Holmberg-DouglasSmall Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, MA, USA.
Farid van der MeiSmall Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, MA, USA.
Paul M ScolaActithera, Cambridge, MA, USA.
Chloe WilliamsSmall Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, MA, USA.
Jeremiah A JohnsonDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-9157-6491
Alison E WendlandtDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. awendlan@mit.edu.ORCID 0000-0003-2970-9817

Funding

Late Stage Stereochemical Editing to Transform the Synthesis of Bioactive MoleculesDP2GM146248 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WENDLANDT, ALISON · 2021 to 2024
$2.1M
NIGMS NIH HHS DP2 GM146248
6 · The paper itself

Abstract

Subtle changes in molecular structure can lead to profound changes in molecular function. However, even minor structural refinements can require the complete resynthesis of a target molecule, adding time and cost to molecular design campaigns

Identifiers

PMID41807648
PMCPMC13242280

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.