Evidence map›Paper›PMID 41807518›Full record

ArticleNPJ precision oncology2026

Dissecting the differentiation origins of intestinal metaplasia and early intestinal-type gastric cancer in gastric antrum by single-cell RNA profiling.

Honghao Yin, Huanyu Zhang, Shuwen Zheng, Rui Guo, Jing Wen, Mengyuan Liu, Aicun Li, Mingfang Zhao, Yuan Yuan, Yuehua Gong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Honghao Yin *Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang, China.
Huanyu Zhang *Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang, China.
Shuwen Zheng *Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang, China.
Rui GuoTumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang, China.
Jing WenTumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang, China.
Mengyuan LiuDepartment of Gastroenterology, the First Hospital of China Medical University, Shenyang, China.
Aicun LiTumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang, China.
Mingfang ZhaoDepartment of Medical Oncology, the First Hospital of China Medical University, Shenyang, China. mfzhao@cmu.edu.cn.
Yuan YuanTumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang, China. yuanyuan@cmu.edu.cn.
Yuehua GongTumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang, China. yhgong@cmu.edu.cn.

Funding

Education Department project of Liaoning Province No. LJ212410159002Education Department project of Liaoning Province No. LJKMZ20221142National Key Research and Development Program of China No. 2023YFB4705700Noncommunicable Chronic Diseases-National Science and Technology Major Project No. 2023ZD0501400
6 · The paper itself

Abstract

Intestinal-type gastric cancer (IGC) is associated with a multi-step carcinogenic process, comprising non-atrophic gastritis, chronic atrophic gastritis, intestinal metaplasia, and gastric dysplasia. The risk of developing IGC gradually increases as the disease progresses. However, the origin of cell differentiation and its carcinogenic potential in different stages of gastric disease remains poorly understood. To address this issue, we analyzed the differentiation trajectory of epithelial cells in different disease stages from gastric antrum biopsies in patients with precancerous lesions and early GC using single-cell sequencing data. Our findings revealed that progenitor cells (PCs) act as the ancestors of antral gland mucous cells (GMCs) and pit mucous cells (PMCs) in the NAG/CAG stage. In the IM stage, GMCs, as well as PCs, may acquire the ability to become intestinal-like stem cell phenotypes, eventually differentiating into mature enterocyte cells. Secretory progenitor cells may differentiate into pre-secretory cells and goblet cells. In the early IGC stage, KIAA0101

Identifiers

PMID41807518
PMCPMC13106798

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.