ArticleScientific reports2026
Punicalagin with anti-inflammatory activities affects Brd-4 mediated chromatin remodeling for attenuating inflammatory osteolysis.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Inflammatory osteolysis is primarily characterized by an extensive macrophage-mediated inflammatory response coupled with osteoclast (OC) formation, triggered by bacterial byproducts and/or environmental stressors. And Osteoarthritis (OA) is one of the most common degenerative diseases in clinical medicine. Currently, anti-inflammatory drugs and intra-articular drug injection are mainly used, but the treatments only relieve symptoms. Punicalagin (PUN), a hydrolyzable tannin derived from pomegranate extract, the suppression of pro-inflammatory cytokine production in macrophages. The therapeutic potential of PUN in alleviating inflammatory osteolysis remains inadequately elucidated. PUN demonstrated favourable biocompatibility and therapeutic potential in vitro, including potent anti-osteoclastic activity, ROS scavenging capacity, and epigenetic regulatory functions. PUN was found to inhibit bromodomain-containing protein 4 (Brd4)-mediated chromatin space remodeling, consequently upregulating the production of endogenous anti-inflammatory factors and antioxidant factors. This study reveals a new therapeutic mechanism that PUN exerts anti-inflammatory effects and regulates epigenetic regulation by influencing Brd4-mediated chromatin remodeling. These findings showed the therapeutic potential of PUN for inflammatory diseases, especially inflammatory osteolysis. Notably, our work identifies a new strategy that synergistically combines osteoclast inhibition with epigenetic regulation, providing a promising direction for the therapies for bone-related inflammatory diseases.
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