Evidence map›Paper›PMID 41807453›Full record

SynthesisNature communications2026

A large-scale genome-wide association meta-analysis for nevus count provides direct insights into the genetics of melanoma.

G J M Shanika R Jayasinghe, Gu Zhu, Nirmala Pandeya, Catherine M Olsen, Nicholas G Martin, Penelope A Lind, Sarah E Medland, Scott D Gordon, Santiago Diaz-Torres, Gareth Lingham and 20 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Unique Features of Melanoma Risk and Diagnosis in Red-Haired Populations.International journal of molecular sciences · 2026
    Review
  4. Article
  5. Functional characterization of the 9q34.13 locus identifiesbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors.

G J M Shanika R JayasingheGenetics and Skin Cancer, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. shanika.jayasinghe@qimrb.edu.au.ORCID http://orcid.org/0000-0002-0782-0445
Gu ZhuGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Nirmala PandeyaCancer Control Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-1462-4968
Catherine M OlsenCancer Control Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-4483-1888
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Penelope A LindSchool of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-3887-2598
Sarah E MedlandSchool of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, QLD, Australia.
Scott D GordonGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Santiago Diaz-TorresSchool of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, QLD, Australia.
Gareth LinghamCentre for Ophthalmology and Visual Science (incorporating the Lions Eye Institute), The University of Western Australia, Nedlands, WA, Australia.ORCID http://orcid.org/0000-0002-8957-0733
Samantha S Y LeeCentre for Ophthalmology and Visual Science (incorporating the Lions Eye Institute), The University of Western Australia, Nedlands, WA, Australia.ORCID http://orcid.org/0000-0001-6635-1098
Tamar NijstenDepartment of Dermatology, Erasmus MC Cancer Institute, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9940-2875
Manfred KayserDepartment of Pathology and Clinical Bioinformatics, Erasmus MC Cancer Institute, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-4958-847X
Luba M PardoDepartment of Dermatology, Erasmus MC Cancer Institute, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0684-3175
Grant W MontgomeryInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-4140-8139
Nicholas K HaywardOncogenomics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Jane M PalmerOncogenomics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
David J HunterDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Jiali HanDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, 1050 Wishard Boulevard, Indianapolis, IN, USA.
Alex W HewittMenzies Institute for Medical Research, School of Medicine, University of Tasmania, Hobart, TAS, Australia.ORCID http://orcid.org/0000-0002-5123-5999
Mario FalchiDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5646-1004
D Timothy BishopLeeds Institute for Data Analytics, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0002-8752-8785
Kevin M BrownDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8558-6711
Veronique BatailleDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
David A MackeyCentre for Ophthalmology and Visual Science (incorporating the Lions Eye Institute), The University of Western Australia, Nedlands, WA, Australia.ORCID http://orcid.org/0000-0001-7914-4709
Mark M IlesLeeds Institute for Data Analytics, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0002-2603-6509
David C WhitemanCancer Control Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
David L DuffyGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Stuart MacGregorSchool of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, QLD, Australia.
Matthew H LawGenetics and Skin Cancer, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. Matthew.Law@qimrb.edu.au.ORCID http://orcid.org/0000-0002-4303-8821

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3M
NCI NIH HHS P30 CA082709
6 · The paper itself

Abstract

A greater understanding of the biology of nevi will provide insights into the etiology of melanoma. Our large-scale meta-analysis of 14 nevus genome-wide association studies (GWAS) includes 85,965 individuals of European ancestry. We identify 29 nevus-associated loci (p < 5 × 10

Indexed as

Genome-Wide Association StudyMelanomaNevusSkin NeoplasmsFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMalePolymorphism, Single Nucleotide

Identifiers

PMID41807453
PMCPMC13106845

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.