Evidence map›Paper›PMID 41807397›Full record

ArticleNature communications2026

Protection of telomeres 1b safeguards the Arabidopsis genome by regulating ROS homeostasis.

Ji-Hee Min, Claudia Castillo-González, Borja Barbero Barcenilla, In-Cheol Yeo, Xiaoyuan Xie, Sreyashree Bose, Fausto Andres Ortiz-Morea, Di Liu, Eli Canal, David Curtis and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ji-Hee Min *Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0002-9213-0464
Claudia Castillo-González *Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.
Borja Barbero Barcenilla *Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0002-5529-5147
In-Cheol YeoDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.
Xiaoyuan XieDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.
Sreyashree BoseDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.
Fausto Andres Ortiz-MoreaDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.
Di LiuDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0002-9981-9969
Eli CanalDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.
David CurtisDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.
Monisha YerramDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.
Joonyoung ShinDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0002-5016-1617
Pavel UlianichDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.
Chinmay PhadkeDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0009-0001-4253-4487
Ping HeDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0002-5926-8349
Andrzej T WierzbickiDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Junjie ZhangDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA.
Eugene V ShakirovDepartment of Biological Sciences, College of Science, Marshall University, Huntington, WV, USA.ORCID http://orcid.org/0000-0003-2689-7410
Thomas E JuengerDepartment of Integrative Biology, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0001-9550-9288
Dorothy E ShippenDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA. dshippen@tamu.edu.ORCID http://orcid.org/0000-0003-0562-2047

Funding

Telomere Structure and Function in ArabidopsisR01GM065383 · NIGMS · TEXAS A&M UNIVERSITY SYSTEM · PI SHIPPEN, DOROTHY · 2002 to 2023
$6.8M
Genetic and epigenetic architecture of natural telomere length variationR01GM127402 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI SHAKIROV, EUGENE V · 2018 to 2025
$2.4M
Signaling activation and constraints in maintaining immune homeostasisR35GM149197 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ping He · 2023 to 2026
$1.2M
National Science Foundation (NSF) MCB 1934703NIGMS NIH HHS R01 GM065383NIGMS NIH HHS R01 GM127402NIGMS NIH HHS R35 GM149197
6 · The paper itself

Abstract

Telomeres safeguard the genome, acting as sentinels of oxidative stress and preventing chromosome ends from eliciting a DNA damage response. PROTECTION OF TELOMERES 1 (POT1) is a highly conserved telomere protein, essential for chromosome integrity and telomeric DNA replication. Arabidopsis thaliana encodes two divergent POT1 paralogs: AtPOT1a stimulates telomerase activity, but AtPOT1b function is unknown. Here we show that AtPOT1b modulates reactive oxygen species (ROS) homeostasis. Oxidative stress induces AtPOT1b expression and telomeric accumulation, while AtPOT1b inactivation elevates ROS, increases telomeric and genome-wide oxidation, and causes stochastic telomere length changes. To address how AtPOT1b controls ROS, we report its localization in nuclei and peroxisomes, and association with catalases and peroxidases that enhance ROS scavenging. Impairing AtPOT1b-CAT2 interaction increases ROS accumulation and telomeric oxidation. Moss or human POT1 rescues ROS overaccumulation in Arabidopsis pot1b mutants, but not telomere deficiency in pot1a pot1b mutants, supporting a conserved role for POT1 in modulating ROS homeostasis and genome stability, distinct from canonical telomeric functions.

Indexed as

ArabidopsisArabidopsis ProteinsGenome, PlantReactive Oxygen SpeciesTelomereTelomere-Binding ProteinsGene Expression Regulation, PlantGenomic InstabilityHomeostasisMutationOxidative StressShelterin ComplexArabidopsis ProteinsPot1 protein, ArabidopsisReactive Oxygen SpeciesShelterin ComplexTelomere-Binding Proteins

Identifiers

PMID41807397
PMCPMC13103404

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.