ArticleNature communications2026
Spatial cartography of human thymus enables the geopositioning of lineage transcription factors in rare mimetic thymic epithelial cells.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Thymic APC Networks Orchestrate T-Cell Selection: Mechanisms and Therapeutic Opportunities in Immune Disorders.Immunology · 2026Review
- AIRE transcriptional condensates in central tolerance: a multiscale mechanistic perspective.Frontiers in immunology · 2026Review
- Network-orchestrated regulation of thymic dysfunction and restoration.Frontiers in immunology · 2026Review
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thymus is the primary site for T cell maturation. While transcriptional profiling of human thymi has been reported, a high-resolution spatial atlas is needed. Here we use Stereo-seq spatial transcriptomics to generate a spatial atlas of the human fetal (13, 14, 17 or 18 weeks post-conception) and pediatric (7 weeks, and 2, 5 or 6 years old) thymi. The architecture of the thymus comprises regions such as the outer cortex, inner medulla, and septa, and contains multiple cell types, including thymic epithelial cells (TEC), thymocytes, dendritic cells, macrophages, and B cells. Utilising this spatial transcriptomics and proteomics information, we further describe lineage-defining transcription factors (TF) that govern molecular signatures of rare mimetic TEC regulation. Our study thus establishes a high-resolution spatial atlas of the human fetal and pediatric thymi to uncover distinct architectural features and TFs regulating these rare cell types, and serves as a resource for further studies.
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