ArticleKorean journal of ophthalmology : KJO2026
Oxidative DNA Damage and Antioxidant Depletion: A Systemic Profile in Primary Open-Angle Glaucoma.
Article in Korean journal of ophthalmology : KJO, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate systemic oxidative stress by comparing serum 8-hydroxy-2'-deoxyguanosine (8-OHdG), coenzyme Q10 (CoQ10), malondialdehyde (MDA), and 25-hydroxyvitamin D (25(OH)D) levels between primary open-angle glaucoma (POAG) patients and healthy controls.
methodsThis prospective case-control study included 37 POAG patients and 35 age-matched controls. Serum levels were measured via enzyme-linked immunosorbent assay. Nonparametric tests (Mann-Whitney U-test and Spearman correlations) and multivariate linear regression adjusting for age and sex were used.
resultsPOAG patients showed significantly higher MDA (3.01 vs. 2.46 nmol/mL, p = 0.021) and 8-OHdG (9.34 vs. 6.52 ng/mL, p < 0.001), but lower CoQ10 (7.28 vs. 8.98 ng/mL, p < 0.001) and 25(OH)D (15.02 vs. 17.45 ng/mL, p = 0.013). MDA and 8-OHdG showed a strong positive correlation (rho = 0.855, p < 0.001). CoQ10 and 8-OHdG showed a moderate positive correlation (rho = 0.466, p = 0.004). No significant correlation was found between 25(OH)D and 8-OHdG (rho = -0.118, p = 0.488). After adjusting for age and sex, POAG remained independently associated with lower CoQ10 (p < 0.001). No oxidative marker correlated with intraocular pressure, visual field mean deviation, or retinal nerve fiber layer thickness in POAG patients (all p > 0.05).
conclusionsPOAG patients exhibit systemic oxidative imbalance with elevated oxidative damage and reduced antioxidant capacity. The positive CoQ10-8-OHdG correlation may suggest a compensatory relationship. This imbalance is associated with POAG but does not correlate with clinical severity cross-sectionally, suggesting it reflects a systemic disease component rather than a direct severity marker.
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