Evidence map›Paper›PMID 41807295›Full record

Observational studyJournal of pediatric gastroenterology and nutrition2026

Significant kidney impairment in pediatric inflammatory bowel disease and practice points for pediatric gastroenterologists.

Stephanie A Vuijk, Renz C W Klomberg, Tobias Schwerd, Anne M Griffiths, Séamus Hussey, Matthew W Carroll, Petter Malmborg, Protima Deb, Margreet Wessels, Natalia Mouratidou and 7 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03571373 (Paediatric Inflammatory Bowel Diseases Network for Safety, Efficacy, Treatment and Quality Improvement of Care), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03571373 recruitingnot on this map

Paediatric Inflammatory Bowel Diseases Network for Safety, Efficacy, Treatment and Quality Improvement of Care: The PIBD-NET Inception Cohort and Safety Registry

Typeobservational_patient_registrySponsorErasmus Medical CenterRan2017 to 2030Enrolled1,500ConditionsInflammatory Bowel Diseases, Crohn Disease, Ulcerative ColitisArmsNo intervention
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Stephanie A VuijkDepartment of Pediatric Gastroenterology, Erasmus Medical Centre - Sophia Children's Hospital, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-2710-7241
Renz C W KlombergDepartment of Pediatric Gastroenterology, Erasmus Medical Centre - Sophia Children's Hospital, Rotterdam, The Netherlands.
Tobias SchwerdDepartment of Pediatrics, Dr von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.
Anne M GriffithsInflammatory Bowel Disease Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Séamus HusseyDOCHAS Group, Children's Health Ireland, Royal College of Surgeons of Ireland and University College Dublin, Dublin, Ireland.
Matthew W CarrollDivision of Pediatric Gastroenterology & Nutrition, Department of Pediatrics, University of Alberta, Edmonton, Canada.
Petter MalmborgDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Protima DebPediatric Gastroenterology, Royal London Children's Hospital, Barts Health NHS Trust, London, UK.
Margreet WesselsDepartment of Pediatrics, Rijnstate Hospital, Arnhem, The Netherlands.
Natalia MouratidouPediatric Gastroenterology, Hepatology and Nutrition Unit, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Stephanie van BiervlietDepartment of Pediatrics, Ghent University Hospital, Ghent University, Ghent, Belgium.
Michael FriedtDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Düsseldorf, Germany.
Susie MinsonDepartment of Pediatrics, Royal London Children's Hospital, Barts Health NHS Trust, London, UK.
Femke H M Vrieling-PrinceDepartment of Pediatric Nephrology, Erasmus Medical Centre - Sophia Children's Hospital, Rotterdam, The Netherlands.
Nicholas M CroftCentre for Immunobiology, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0002-1519-6435
Lissy de RidderDepartment of Pediatric Gastroenterology, Erasmus Medical Centre - Sophia Children's Hospital, Rotterdam, The Netherlands.
PIBD‐SETQuality Safety Registry Collaborative Group

Funding

European Union Horizon 668023
6 · The paper itself

Abstract

objectivesChildren with inflammatory bowel disease (IBD) have an increased risk of developing kidney disorders, which may cause significant kidney function impairment (SKI) or lead to chronic kidney disease (CKD). In this study we aimed to provide insights in causes and diagnoses of SKI cases and to provide recommendations for pediatric gastroenterologists for children with IBD and SKI.

methodsCases of SKI in children with IBD (<19 years) were collected from the international, prospective PIBD-SETQuality Safety Registry. A monthly survey was sent to participating pediatric gastroenterologists to report cases of SKI (defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m

resultsBetween November 1, 2016 and December 31, 2023, 42 cases of SKI were eligible for analysis. Tubulo-interstitial nephritis (TIN) was the most common diagnosis (n = 15). Sixteen (38%) cases were confirmed with renal biopsy (10 cases of TIN). Twelve patients developed CKD. IBD medication was the most frequently reported cause (n = 15), however, there was low concordance between panelists about the most likely etiology (Fleiss' kappa 0.143 and 0.102).

conclusionsThis is the first prospective study to report cases of SKI in children with IBD. SKI may lead to CKD. Confirming the etiology of the SKI proved to be very challenging. The study provides recommendations for screening and follow-up of SKI in children with IBD.

trial registrationNCT03571373, date of registration: June 27, 2018, URL: https://clinicaltrials.gov/study/NCT03571373.

Indexed as

Inflammatory Bowel DiseasesRenal Insufficiency, ChronicAdolescentChildChild, PreschoolFemaleGastroenterologistsGastroenterologyGlomerular Filtration RateHumansMaleProspective StudiesRegistriesCrohn's diseaserenalulcerative colitis

Identifiers

PMID41807295
PMCPMC13150792

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.