Evidence map›Paper›PMID 41807289›Full record

ArticleJournal of cosmetic dermatology2026

Evaluation of a 10% Urea Lotion for Xerosis: Clinical and Patient-Reported Outcomes From a Prospective Study.

Nemanja Maletin, Bojana Spasić, Zoran Golušin, Ivana Binić, Miloš Nišavić, Marija Ranđelović, Maša Golubović, Stefan Borocki, Lazar Marin, Iva Binić and 1 more

Abstract readClinical Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nemanja MaletinFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.ORCID https://orcid.org/0009-0009-8592-0685
Bojana SpasićClinic for Dermatovenerology, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Zoran GolušinFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Ivana BinićClinic for Dermatovenerology, University Clinical Center Niš, Niš, Serbia.
Miloš NišavićFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Marija RanđelovićClinic for Dermatovenerology, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Maša GolubovićClinic for Dermatovenerology, University Clinical Center Niš, Niš, Serbia.
Stefan BorockiFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Lazar MarinFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Iva BinićDepartment of Psychiatry, Medical Faculty, University of Niš, Niš, Serbia.ORCID https://orcid.org/0000-0002-6457-990X
Nikola DendaFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

Funding

Planinka d.o.o.-Prolom Banja
6 · The paper itself

Abstract

introductionXerosis cutis is a common skin condition characterized by dryness, scaling, and pruritus due to impaired barrier function and reduced natural moisturizing factors. This study aimed to evaluate the clinical efficacy of a 10% urea lotion in adults with xerosis and assess participant satisfaction with the product.

methodsA prospective, single-arm clinical study was conducted over 60 days in adults with confirmed xerosis. Participants applied a 10% urea lotion with Prolom thermal water twice daily. Skin hydration and elasticity were measured by corneometry and cutometry at baseline, day 14, day 30, and day 60. Subjective outcomes were assessed using a product satisfaction questionnaire and the Skindex-16 scale. Data were analyzed using repeated measures ANOVA with p < 0.05 considered significant.

resultsSignificant improvements were observed in skin hydration (+55.3%) and elasticity (+55%), as well as reductions in redness, scaling, and itching (all p < 0.001). Skindex-16 total scores improved by 61%, reflecting enhanced quality of life. The lotion was well tolerated, with no significant adverse effects, and participants reported high satisfaction and willingness to continue use.

conclusionThe 10% urea lotion with Prolom thermal water demonstrated significant clinical efficacy in improving hydration, elasticity, and overall skin condition in adults with xerosis over a 60-day period. The treatment was well tolerated and associated with high patient satisfaction and a marked improvement in quality of life.

Indexed as

Skin CreamSkin DiseasesUreaAdministration, CutaneousAdultAgedElasticityFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresPatient SatisfactionProspective StudiesPruritusQuality of LifeUreadry skinepidermal barrierProlom thermal waterskin hydrationureaxerosis

Identifiers

PMID41807289
PMCPMC12975674

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.