Evidence map›Paper›PMID 41807253›Full record

ArticlePediatric dermatology

Nail Disorders in Children With Down Syndrome: A Multicenter Study.

Sezgi Sarikaya Solak, Filiz Cebeci Kahraman, İsa An, Hilal Kaya Erdogan, Selma Emre, Rukiye Yasak, Ilkin Zindanci, Ferdi Ozturk, Sevilay Kilic, Eda Oksum Solak and 10 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Sezgi Sarikaya SolakDepartment of Dermatology, Faculty of Medicine, Trakya University, Edirne, Türkiye.ORCID https://orcid.org/0000-0002-8572-8249
Filiz Cebeci KahramanDepartment of Dermatology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.ORCID https://orcid.org/0000-0002-9109-3892
İsa AnDepartment of Dermatology, Sanliurfa Training and Research Hospital, Sanliurfa, Türkiye.ORCID https://orcid.org/0000-0003-3366-4551
Hilal Kaya ErdoganDepartment of Dermatology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Türkiye.
Selma EmreDepartment of Dermatology, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Türkiye.
Rukiye YasakDepartment of Dermatology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Türkiye.ORCID https://orcid.org/0000-0002-5154-4652
Ilkin ZindanciHaydarpaşa Numune Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Ferdi OzturkDepartment of Dermatology, Faculty of Medicine, Uludag University, Bursa, Türkiye.
Sevilay KilicDepartment of Dermatology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Türkiye.
Eda Oksum SolakDepartment of Dermatology, Faculty of Medicine, Erciyes University, Kayseri, Türkiye.ORCID https://orcid.org/0000-0002-1362-7801
Sevil Savas ErdoganDepartment of Dermatology Sultan 2, Abdülhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Tugba Kontbay CetinSanliurfa Training and Research Hospital, Clinic of Pediatric Endocrinology, Sanliurfa, Türkiye.
Kursad Bora CarmanDepartment of Pediatric Neurology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Türkiye.ORCID https://orcid.org/0000-0002-4629-1873
Mehmet BoyrazDepartment of Pediatric Endocrinology, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Türkiye.
Nurullah CelikDepartment of Pediatrics, Division of Pediatric Endocrinology, Faculty of Medicine, Cumhuriyet University, Sivas, Türkiye.
Ozlem Akgun DoganDivision of Pediatric Genetics, Department of Pediatrics, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Türkiye.
Tugberk AkcaDepartment of Pediatric Cardiology, Faculty of Medicine, Uludag University, Bursa, Türkiye.ORCID https://orcid.org/0000-0002-2747-974X
Durmuş DoganDepartment of Pediatrics, Division of Pediatric Endocrinology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye.
Ülkü Gül ŞirazDepartment of Pediatric Endocrinology, Faculty of Medicine, Erciyes University, Kayseri, Türkiye.
Suna KilincDepartment of Pediatric Endocrinology, University of Health Sciences Zeynep Kamil Women and Children Diseases Training and Research Hospital, Istanbul, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesAlthough skin diseases in Down syndrome (DS) have been investigated, nail disorders remain understudied. This study aims to evaluate the prevalence and clinical characteristics of nail disorders in children with DS.

methodsThis is a multicenter, case-control study in which 221 children with DS and 160 healthy children were recruited from 9 tertiary dermatology centers. A detailed nail and skin examination was performed by an experienced dermatologist in each center. Nail disorders were recorded.

resultsOf the 221 children with DS, 57% (126/221) had at least one nail disorder. The prevalence of nail disorders in the DS group was significantly higher than in the control group (p ≤ 0.001). Brittle nail was the most common nail disorder (19.0%, 42/221) in children with DS, followed by Beau's lines and onychomadesis (16.3%, 36/221), longitudinal ridging (12.7%, 28/221), and self-induced nail disorders (onychophagia, habitual tic deformity, and onychotillomania) (10.0%, 22/221). The risk of any nail disorder was 3 times higher, brittle nails 4.3 times, Beau's lines and onychomadesis 5.6 times, self-induced nail disorders 1.6 times, and longitudinal ridging 3.4 times higher in DS compared to the control group (p < 0.05).

conclusionsNail disorders, including brittle nails, Beau's lines, and onychomadesis, self-induced nail disorders, and longitudinal ridging, are common in DS. The identification of nail disorders in DS may aid in recognizing underlying systemic or psychiatric conditions, thereby supporting more comprehensive care for children with DS.

Indexed as

Down SyndromeNail DiseasesAdolescentCase-Control StudiesChildChild, PreschoolFemaleHumansInfantMalePrevalenceBeau's linesbrittle nailschildrenDown syndromenail disordersonychophagiaonychothillomania

Identifiers

PMID41807253
PMCPMC13422997

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