Evidence map›Paper›PMID 41807087›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2026

Elevation of Stearoyl-Coenzyme A Desaturase and Monounsaturated Fatty Acids in Parkinson's Disease Serum.

Finula I Isik, Russell Pickford, Michelle Chua, Simon J G Lewis, Nicolas Dzamko, Woojin Scott Kim

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Article in Movement disorders : official journal of the Movement Disorder Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Finula I IsikBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Russell PickfordBioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, New South Wales, Australia.
Michelle ChuaBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Simon J G LewisMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
Nicolas DzamkoBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Woojin Scott KimBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-4707-933X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmerging evidence indicates that dysregulation of monounsaturated fatty acids (MUFAs), synthesized by the enzyme stearoyl-coenzyme A desaturase (SCD), impacts on α-synuclein pathology in the Parkinson's disease (PD) brain.

objectiveThe objective of this study was to analyze SCD and MUFA-enriched lipids in the periphery of patients with sporadic PD compared with healthy control subjects.

methodsSerum SCD protein was quantified using enzyme-linked immunosorbent assay in patients with PD (n = 40) and control subjects (n = 41). Lipidomic profiling was performed using liquid chromatography-mass spectrometry and LipidSearch software. Statistical analyses included Mann-Whitney U tests and Welch's t tests with false discovery rate (FDR) correction.

resultsSCD levels were higher in PD (mean = 1702 pg/ml) compared with control subjects (1158 pg/ml; P = 2.2 × 10

conclusionsIncreased SCD and MUFA-enriched lipids indicate altered membrane and sphingolipid metabolism in PD, consistent with central disease pathology, that present a potential for novel biomarker development for PD. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Indexed as

Fatty Acids, MonounsaturatedParkinson DiseaseStearoyl-CoA DesaturaseAgedFemaleHumansMaleMiddle AgedFatty Acids, MonounsaturatedStearoyl-CoA Desaturaselipidmonounsaturated fatty acidParkinson's diseasestearoyl‐CoA desaturase

Identifiers

PMID41807087
PMCPMC13518281

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.