Trial reportAmerican journal of perinatology2026
Association between Neonatal Hypoglycemia and 30-Day Breastfeeding Outcomes among Gravidas with Type 2 Diabetes.
Trial report in American journal of perinatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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16 authors.
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Abstract
Objective: Pregestational diabetes is associated with low prevalence of breastfeeding due to low rates of intent, delayed lactogenesis, and early infant separation. It is hypothesized that the perceived need for formula supplementation due to neonatal hypoglycemia, coupled with maternal low early milk supply, is a barrier to breastfeeding initiation. Whether there is an association between neonatal hypoglycemia and breastfeeding is unknown. We evaluated associations between neonatal hypoglycemia and breastfeeding. Study Design: This is a secondary analysis of a randomized controlled trial of metformin versus placebo plus insulin in participants with type 2 diabetes. We included participants who delivered a liveborn neonate, endorsed intention to breastfeed, and had neonatal hypoglycemia data available. A breastfeeding questionnaire was administered at 30-day postpartum, and outcomes were compared between neonates with and without hypoglycemia. The primary outcome was prevalence of exclusive, partial, or no breastfeeding at 30-day postpartum. Secondary outcomes included time to breastfeeding cessation and contributing factors. Characteristics were compared with chi-square, Results: A total of 420 participants in the primary study (53%) completed an antepartum survey, including a question about intent to breastfeed. After exclusion criteria were applied, 370 (91%) of 405 possible participants reported intention to breastfeed. Among these 370 who met criteria and had intention to breastfeed, 265 (72%) responded to the 30-day postpartum questionnaire. Of these 265, 114 (43%) had neonatal hypoglycemia and 151 (57.0%) did not. Prevalence of not breastfeeding (35 vs. 37%), exclusive breastfeeding (18 vs. 13%), and partial breastfeeding (47 vs. 50%) did not differ between neonates with and without hypoglycemia ( Conclusion: This study found no impact of neonatal hypoglycemia on 30-day postpartum breastfeeding prevalence among participants with diabetes. Key Points: · Type 2 diabetes reduces the likelihood of breastfeeding, and the barriers are not fully known.. · Neonatal hypoglycemia is hypothesized to be one barrier to breastfeeding among this population.. · Neonatal hypoglycemia did not impact breastfeeding among diabetic gravidas 30-day postpartum.. · This remained true among neonates admitted to the neonatal intensive care unit.. · Further research examining barriers to breastfeeding among gravidas with diabetes is needed..
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