Evidence map›Paper›PMID 41806839›Full record

ArticleCell reports. Medicine2026

LIFUS-driven engineered bacteria reprogram immunosuppressive niches via mechano-NOTCH signaling.

Lizhou Lin, Xiao Li, Wenyun Guo, Jirong Xie, Xiaolong Li, Xin Guan, Chongke Zhao, HaoHao Yin, Huixiong Xu

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Lizhou LinDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Xiao LiDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Wenyun GuoDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Jirong XieDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Xiaolong LiDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Xin GuanDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Chongke ZhaoDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
HaoHao YinDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China. Electronic address: yin.haohao@zs-hospital.sh.cn.
Huixiong XuDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China. Electronic address: xu.huixiong@zs-hospital.sh.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solid tumors impose coupled stromal and immunologic barriers that limit T cell infiltration and function. Here, we engineer Salmonella VNP20009 to express gas vesicles (GVs), creating an intratumoral cavitation source that converts low-intensity focused ultrasound (LIFUS) into localized mechanical forces. LIFUS-activated GVs remodel the tumor microenvironment by reducing cancer-associated fibroblast (CAF) abundance, decompressing the matrix, and selectively disrupting CAF-CD8

Indexed as

Receptors, NotchSalmonellaTumor MicroenvironmentAnimalsCD8-Positive T-LymphocytesCell Line, TumorHumansMechanotransduction, CellularMiceSignal TransductionReceptors, NotchimmunotherapymechanotransductionNOTCH pathwaytumor microenvironmentultrasound

Identifiers

PMID41806839
PMCPMC13006435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.